中国汉族人群的血清谷丙转氨酶水平正常上限

肝胆速递

http://www.ncbi.nlm.nih.gov/pubmed/22962588##
PLoS One. 2012;7(9):e43736. Epub 2012 Sep 4.
Upper limits of normal for serum alanine aminotransferase levels in chinese han population.
Zheng MH, Shi KQ, Fan YC, Liu WY, Lin XF, Li LF, Chen YP.
Source

Department of Infection and Liver Diseases, Liver Research Center, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.
Abstract
BACKGROUND AND OBJECTIVES:

Serum alanine aminotransferase (ALT) activity is the most common tool for the assessment of liver diseases. However, it is not clear whether the current normal ALT range really discriminate patients with or without liver diseases. The present study was to establish a new normal range of ALT and examine its ability to identify patients with hepatitis B or nonalcoholic fatty liver disease (NAFLD) in Chinese Han population.
METHODS:

53037 adults were included in this study from January 1st 2008 to August 31st 2010. The 95th percentile of ALT in population with relative low risk factors for liver diseases was set as the new upper limits of normal ALT in gender-specific manner.
RESULTS:

The 95(th) percentile levels at low risk factors for liver diseases were achieved at 35 U/L for men and 23 U/L for women. The concordance statistics for detection were 0.873 (95%CI: 0.865-0.881) for HBV and 0.932 (95%CI: 0.927-0.937) for NAFLD in men while 0.857 (95%CI: 0.850-0.864) for HBV and 0.909 (95%CI: 0.903-0.915) for NAFLD in women. The median sensitivity of the current used ALT upper limit (40 U/L) was 6.6% for HBV and 29.7% for NAFLD and median specificity was 98.7% for men and 99.4% for women. Using our new-derived thresholds, the sensitivities ranged from 35.3% to 61.1% and the specificities were 94.8% for men and 94.6% for women.
CONCLUSIONS:

Our results suggest that upper limits of ALT 35 U/L for men and 23 U/L for women in Chinese Han population. Re-consideration of normal limits of ALT should be recommended.

肝胆速递

公共科学图书馆之一。2012年7（9）：e43736。 EPUB2012年9月4日。
中国汉族人群的血清谷丙转氨酶水平在正常上限。
郑MH，石KQ，范YC，刘WY李，林XF，LF，陈YP。
源

系感染与肝病，肝病研究中心，附属第一医院，温州医学院，温州，中国。
抽象
背景和目的：

血清丙氨酸氨基转移酶（ALT）活性是最常见的肝脏疾病的评估工具。然而，ALT正常范围目前尚不清楚是否真的歧视伴或不伴疾病患者。本研究是建立一个新的ALT正常范围内，并检查其能力，以确定患者B型肝炎或酒精性脂肪性肝病（NAFLD）在中国汉族人群中。
方法：

在这项研究从2008年1月1日至2010年8月31日，53037名成人。不同性别的方式作为新的ALT正常上限的第95百分位ALT人口与相对较低的肝脏疾病的危险因素。
结果：

95（日）百分水平低肝脏疾病的危险因素，达到35 U/ L的男性和23 U/ L为女性。的一致性统计检测HBV0.873（95％CI：0.865-0.881）和0.932（95％CI：0.927-0.937），非酒精性脂肪肝的男性HBV0.857（95％CI：0.850-0.864）和0.909（95 ％CI：0.903-0.915），非酒精性脂肪肝的妇女。目前所使用的ALT上限（40 U/ L）的平均灵敏度为6.6％，HBV和非酒精性脂肪肝和中位数的特异性为29.7％，98.7％的男性和99.4％的女性。使用我们的新派生的阈值，由35.3％至61.1％不等的敏感性和特异性分别为94.8％的男性和94.6％的女性。
结论：

我们的研究结果表明，ALT35 U/ L的男性和23 U/ L为在中国汉族人群中的妇女的上限。应重新考虑正常范围内的ALT建议。
临床试验注册：

ChiCTR.org中国中心-OCS-11001173。

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