拉米耐药株导致的肝炎的临床特征及肝炎慢性化

肝胆速递

Source: J Med Virol  |  Posted 1 week ago

Clinical characteristics and chronicity of acute hepatitis B induced by
lamivudine-resistant strains
拉米耐药株导致的肝炎的临床特征及肝炎慢性化

; Luo Q, Zhong Y, Yang Y, Xiong Q, Hu Z, Lu W,
Huang P, Zhang N; Journal of Medical Virology 84 (10), 1558-61 (Oct 2012)

Tags:
Hepatitis
lamivudine

Whether resistant hepatitis B virus (HBV) strains are transmissible and can
lead to chronic infection remains to be studied. The aim of this study was
to investigate the clinical characteristics of patients with acute
hepatitis B caused by lamivudine (LAM)-resistant strains. Sera were
collected from 234 Chinese patients with acute hepatitis B. LAM-resistance
mutations were identified by direct polymerase chain reaction (PCR)
sequencing. LAM-resistant HBV variants were detected in 11 of the 234
(4.7%) patients. Among these patients, six harbored the rtM204I mutation,
two harbored the rtL180M + rtM204I mutations, one harbored the
rtM204I + rtM204V mutations, one harbored the rtL80I + rtM204I
mutations, and one harbored the rtV173L + rtL180M + rtM204V
mutations. Three patients were infected with genotype B HBV and eight
patients were infected with genotype C HBV. Two patients infected with
viruses with LAM-resistance mutations developed severe acute hepatitis. One
patient developed chronic hepatitis B. This patient was infected with
genotype C HBV that had LAM-resistance mutations (rtL180M + rtM204I).
The patient was diagnosed with an occult hepatitis B virus infection based
on the presence of HBV DNA in the liver and the absence of detectable
hepatitis B surface antigen (HBsAg) in the serum. LAM-resistant HBV strains
in China are transmissible, can cause acute hepatitis B, and can even
progress to chronic infection in China. J. Med. Virol. 84:1558-1561, 2012.
© 2012 Wiley Periodicals, Inc

肝胆速递

资料来源：J医学病毒学杂志|发表于1周前

诱发急性B型肝炎的临床特征及慢性
拉米夫定耐药株;罗Q，钟Ÿ，杨，熊Q，胡，鲁W，
黄P，张娜，医学病毒学杂志84（10），1558年至1561年（2012年10月）

标签：
肝炎
拉米夫定
读/新增评论||打印此页|期刊

抗B型肝炎病毒（HBV）的菌株是否是传染性的，并能
导致慢性感染，还有待研究。本研究的目的是
急性期病人的临床特征
拉米夫定（LAM）耐药株B型肝炎引起的。血清
收集从234例急性B型肝炎林耐
通过直接的聚合酶链反应（PCR）突变鉴定
测序。林抗HBV变异株中检测到11的234
（4.7％）患者。在这些患者中，有6窝藏rtM204I突变，
窝藏为rtL180M+ rtM204I突变，窝藏
rtM204I+ rtM204V突变，窝藏的rtL80I的+ rtM204I
突变，窝藏rtV173L+为rtL180M+ rtM204V
突变。 3例患者感染B基因型和8
C基因型HBV感染患者。两名患者感染
林耐药突变的病毒发展成严重的急性肝炎。一
患者发展为慢性B型肝炎病人感染
C基因型HBV，林耐药突变（为rtL180M+ rtM204I）。
患者被诊断为隐匿性乙肝病毒感染的
在肝脏中的HBV DNA的存在的情况下探测
血清中的B型肝炎表面抗原（HBsAg）。林抗HBV病毒株
在中国的传播，可以引起急性B型肝炎，甚至可以
在中国的发展为慢性感染。 J.医学。病毒学84:1558-1561，2012年。
©2012威利期刊公司

咬牙硬挺

耐药的病毒传染开来那就麻烦大了，不过也能促进新药研发