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本帖最后由 肝胆速递 于 2012-9-15 16:59 编辑
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.07050.x/abstract
Viral response at 6 months is associated with treatment outcome of adefovir add-on therapy for lamivudine-resistance
拉米耐药患者在6个月对阿德福韦的病毒反映和治疗结果相关
肝胆速递:约31.5月对559的乙肝患者跟踪研究显示,拉米耐药患者在增加阿德福韦治疗后6个月后取得DNA阴性和最终清除血液中HBV的DNA相关
Yu Jin Kim等
Article first published online: 21 AUG 2012
Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
*Professor Seung Woon Paik, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea. E-mail: [email protected]
Abstract
Background and Aim: Adefovir add-on therapy is recommended for patients infected with lamivudine-resistant hepatitis B virus (HBV). We aimed to describe the long-term treatment outcome and predictors for good response of adefovir add-on therapy.
Methods: A total of 559 chronic hepatitis B (CHB) patients who had been treated for at least 12 months with adefovir add-on therapy due to resistance to lamivudine were retrospectively included. Complete virologic response (CVR) was defined as serum HBV DNA < 9 IU/mL. Viral responses at 6 months were classified as PCR negativity, partial virologic response (PVR, HBV DNA < 2000 IU/mL), or inadequate virologic response (IVR, HBV DNA ≥ 2000 IU/mL).
Results: The median duration of follow-up was 31.5 months (range, 12–56). The cumulative probabilities of CVR during adefovir add-on therapy were 58%, 70%, 78%, and 80% at 12, 24, 36, and 43 months, respectively. The cumulative rates of resistance to adefovir were 0.4%, 0.8%, and 3.1% at 12, 24, and 36 months, respectively. The only baseline factor associated with CVR (hazard ratio 0.83, 95% confidence interval 0.62–0.91, P ≤ 0.001) and resistance to adefovir (hazard ratio 1.925, 95% confidence interval 1.13–3.30, P = 0.017) was serum HBV DNA level. Comparison of the cumulative rates of CVR and resistance to adefovir according to viral response at 6 months showed significant differences among the three groups (P < 0.0001 and P = 0.0005, respectively).
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