基因型对慢性乙肝的影响

肝胆速递

Genotype impact on long-term virological outcome of chronic hepatitis B virus infection
基因型对慢性乙肝的影响

肝胆速递：HBV基因型A，B和D型的DNA载量可随时间逐渐下降，但高复制的C或者D型常常持续高复制

Genotype impact on long-term virological outcome of chronic hepatitis B virus infection

    Sebastian Malmström    ,
    Anders Eilard    ,
    Simon B. Larsson    ,
    Charles Hannoun    ,
    Gunnar Norkrans    ,
    Magnus Lindhemail address

Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Received 14 December 2011; received in revised form 22 February 2012; accepted 17 April 2012. published online 21 May 2012.

Abstract
Background

The importance of hepatitis B virus (HBV) genotype on the clinical course of chronic HBV infection is not yet clarified.
Objectives

To investigate genotype impact on long-term virological outcome of chronic HBV infection.
Study design

HBsAg, HBeAg, ALT and HBV DNA levels were determined after a median of 9.2years of follow-up of 124 adults with chronic HBV infection, of whom 33 were HBeAg-positive at inclusion.
Results

HBV DNA levels decreased significantly in patients carrying genotype A (n=28), B (n=21) or D (n=63), but not in those with genotype C infection (n=12). Loss of HBeAg was seen in 44% (4/9) of patients with genotype C, as compared with 92% (22/24) with non-C genotypes. Loss of HBsAg was seen in 36% (10/28) patients with genotype A, 5% (1/21) with B, 0% (0/12) with C, and 11% (7/63) with genotype D.
Conclusions

HBV DNA levels decreased over time in patients infected with genotypes A, B or D. However, highly active genotype C or D infection often remained highly active, implying a risk for progressive liver damage.

B型肝炎病毒（HBV）基因型对慢性HBV感染的临床过程的重要性尚未明确。
目标

调查基因型的影响，长期的慢性HBV感染者的病毒学结果。
研究设计

乙型肝炎表面抗原（HBsAg），e抗原，ALT和HBV DNA水平确定后，中位数为9.2年后续的124名成人慢性HBV感染者，其中33例HBeAg阳性的，包容的。
结果

HBV DNA水平下降明显的患者进行基因型A（N =28），B（N= 21）或D组（n =63），而不是在那些与C基因型感染者（n =12）。 HBeAg消失，92％（22/24），与非C基因型相比，C基因型的患者中有44％（4/9）。 HBsAg消失36％（10/28）患者的基因型A，5％（1/21），其中B，C，0％（0/12）和11％（7/63），基因型D。
结论

随着时间的推移感染基因型A，B或D。然而，高活性基因型C或D感染的患者HBV DNA水平下降，经常保持高度活跃，暗示性肝损伤的风险。

咬牙硬挺

我们离胜利还有很远的距离

疯一点好

肝胆速递是斯帝芬吗？好像他的风格。