本帖最后由 StephenW 于 2012-7-25 06:52 编辑
Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid Qing Mao, Hui-Yan Zhang, Jian-Ping You and Xu-Qing Zhang
Virology Journal 2012, 9:136 doi:10.1186/1743-422X-9-136
Published: 24 July 2012
Abstract (provisional)Severe acute exacerbation or liver failure induced by standard interferon-alpha(IFN-alpha) therapy had been reported to occur in few patients with chronic hepatitis B. However, no report showed that pegylated interferon-alpha therapy was able to induce severe acute exacerbation of chronic hepatitis B. Here, we describe three patients with severe acute exacerbation of chronic hepatitis B during pegylated interferon-alpha2a (Pegasys) treatment. One patient progressed into acute-on-chronic liver failure (ACLF) at the second week of Pegasys treatment. Two patients progressed into acute-on-chronic pre-liver failure (pre-ACLF) at the second and eighth week of Pegasys treatment, respectively. Three patients recovered after early intervention with corticosteroid and lamivudine. Our data indicated that there was a risk of severe acute exacerbation among patients with chronic hepatitis B during receiving Pegasys treatment. Importantly, early intervention with corticosteroid should be introduced to prevent the disease progression and improve their prognosis once severe acute exacerbation was diagnosed. | 
发表于 2012-7-25 06:51
