Nancocure for hepatitis

StephenW

doi:10.1038/nindia.2012.102; Published online 17 July 2012
Nanocure for hepatitis, rhinitis

Researchers have designed a novel nanoparticle-based technique for treating hepatitis B and allergic rhinitis^1 <http://cirrus.mail-list.com/hepatitis-b/33642103.html> . The hepatitis B virus surface antigen (HBsAG)-loaded nanoparticles can be delivered through the nasal passage, offering an effective therapy for treating hepatitis B infection.

Infection with the hepatitis B virus (HBV) causes irritation and swelling of the liver. HBV claims many lives despite the availability of an HBV vaccine. In addition, proper vaccination requires three doses; those allergic to HBV cannot take all the doses.

To find an alternative and effective therapy, the researchers loaded trimethyl chitosan nanoparticles with HBsAG. They studied the nanoparticles' efficacy to release the antigen.

Drug release studies revealed that 93% of the HBsAG was released over a period of 43 days. Studies in female mice showed that antigen-loaded nanoparticles were highly stable and better than standard therapy techniques.

In addition, the size and surface properties of the nanoparticles can be tailored by modifying the concentration of trimethyl chitosan nanoparticles.

The researchers say that the nanoparticles can be extensively used in controlled intranasal delivery of drug molecules to treat hepatitis B. They add that these nanoparticles could also be used to treat allergic rhinitis --- inflammation of the nose and eyes due to inhalation of allergens such as dust, dander and pollen.

The authors of this work are from: University of Science and Technology (UST), Gwahangno, Yuseong-gu, Daejon, Biomaterials Center, Korea Institute of Science and Technology (KIST), Hawolgok, Seoul, School of Mechanical & Advanced Materials Engineering, and Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea and Department of Pharmaceutics, Nandha College of Pharmacy, Erode, Tamil Nadu, India.

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       References

    1. Subbiah, R. et al. N, N, N-trimethyl chitosan nanoparticles for
       controlled intranasal delivery of HBV surface antigen.
       Carbohydr. Polymer. 89, 1289-1297 (2012)

StephenW

DOI：10.1038/nindia.2012.102;线上发表于2012年7月17日
nanocure为肝炎，鼻炎

研究人员设计了新型的基于纳米技术为治疗乙型肝炎和过敏性鼻炎^ 1 <http://cirrus.mail-list.com/hepatitis-b/33642103.html&gt;。乙肝病毒表面抗原（HBsAg）纳米粒可通过鼻腔交付，提供了一个用于治疗乙型肝炎病毒感染的有效治疗。

与B型肝炎病毒（HBV）感染引起的肝脏发炎和肿胀。提供乙肝疫苗乙肝病毒声称，尽管许多人的生命。此外，适当的疫苗接种需要三剂过敏者对HBV不能把所有的剂量。

找到一个替代的和有效的治疗方法，研究人员装有三甲基壳聚糖纳米粒子的表面抗原。他们研究了纳米颗粒的药效释放抗原。

药物释放的研究显示，93％的乙肝表面抗原，通过为期43天公布。在雌性小鼠的研究表明，抗原纳米粒高度稳定和优于标准治疗技术。

此外，纳米粒子的大小和表面特性，可以根据修改三甲基壳聚糖纳米粒子的浓度。

研究人员说，纳米粒子可以被广泛用于滴鼻药物分子在控制交付治疗B型肝炎，他们补充说，这些纳米粒子也可用于治疗过敏性鼻炎---鼻子和眼睛发炎因吸入过敏原，如灰尘，皮屑和花粉。

这项工作的作者是：科技大学（科大），Gwahangno儒区，大田，生物材料中心，科学和技术研究院（KIST），Hawolgok，汉城，机械及先进的材料工程学院，蔚山科学技术研究所（UNIST），蔚山，韩国和药学系，Nandha药学院共和国，侵蚀，印度泰米尔纳德邦。

StephenW

这可能是一种新的方式，传递有效的预防B型肝炎疫苗.

咬牙硬挺

只是接种疫苗吗？有治疗功效吗

咬牙硬挺

只是接种疫苗吗？有治疗功效吗

咬牙硬挺

只是接种疫苗吗？有治疗功效吗

咬牙硬挺

只是接种疫苗吗？有治疗功效吗

StephenW

咬牙硬挺 发表于 2012-7-18 18:57
只是接种疫苗吗？有治疗功效吗

预防.有治疗功效?不知道.