Minimization of HBV Infection by A 25-Year Universal Vaccination Program.

StephenW

J Hepatol. 2012 Jun 2. [Epub ahead of print]
Minimization of HBV Infection by A 25-Year Universal Vaccination Program.Ni YH, Chang MH, Wu JF, Hsu HY, Chen HL, Chen DS.
SourceDepartment of Pediatrics, Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

AbstractBACKGROUND & AIM: Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program.
METHODS: We enrolled 3,332 subjects younger than 30 years of age with approximately 100 in each age cohort. Subjects were recruited voluntarily from schools and other institutions in Taipei, as in previous surveys. HBV seromarkers, included hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) and to hepatitis B core antigen (anti-HBc). HBV DNA levels were determined in subjects that were anti HBc positive/ HBsAg negative (anti-HBc only).
RESULTS: The HBsAg, anti-HBs, and anti-HBc seropositive rates were very different between those born after the program in 2009 and the baseline group in 1984 (0.9% vs. 10%, 55.9% vs. 24.5%, and 7.0% vs. 28%, respectively). HBsAg prevalence further decreased in the vaccinated cohorts in this 6th survey. A positive maternal HBsAg status was found in 86% of vaccine failures. Serum HBV DNA was detected in 4.2 % (6/142) of anti-HBc positive/ HBsAg negative subjects with a low level of HBV DNA. All of these six subjects' HBV were genotype C.
CONCLUSIONS: The universal infant HBV immunization program in Taiwan has completed its 25-year follow-up and its efficacy in young adults is clear. The continued decrease in HBsAg prevalence suggests that the elimination of HBV infection is becoming a reality.

StephenW

J肝胆病杂志。2012年俊2。 [出处提前打印]
乙肝病毒感染的最小化了25年的通用疫苗接种计划。
镍张玉海，张氢，吴摩根富林明，许兴业，陈汉林，陈德尚。
源

儿科医院和医学院，国立台湾大学，台北，台湾。
抽象
背景与目的：

在台湾B型肝炎病毒（HBV）感染高度流行之前普遍婴儿乙肝疫苗接种计划，这是在1984年推出的实施。五年以前的血清流行病学进行了调查，在0，5，10，15，20年后推出的疫苗接种计划。
方法：

我们参加3332受试者年龄小于30岁，每个年龄组中有大约100。受试者招募自愿从台北的学校和其他机构，在以往的调查。乙肝seromarkers，包括乙肝表面抗原（HBsAg）和乙肝表面抗原（抗-HBs）和乙肝核心抗原（抗-HBc）的抗体。 HBV DNA水平的受试者中，抗HBc阳性/ HBsAg阴性（抗-HBc）。
结果：

计划在2009年后出生的人，在1984年的基线组（0.9％和10％，55.9％与24.5％，7.0％和之间的HBsAg，抗-HBs，抗-HBc阳性率非常不同28％，分别）。 HBsAg的患病率进一步下降，在这6调查接种同伙。产妇乙肝表面抗原阳性的地位被发现在86％的疫苗失败。血清HBV DNA检测抗-HBc阳性/ HBsAg的负面科目与HBV DNA的水平低4.2％（6/142）。所有这六个科目的乙肝病毒C基因型
结论：

台湾普遍婴儿乙肝病毒免疫程序已经完成了25年的后续行动和其在青壮年中的疗效是明确的。在HBsAg流行率持续下降表明，消除乙肝病毒感染正在成为现实。