Genotype impact on long-term virological outcome of chronic hepatitis B virus in

StephenW

J Clin Virol. 2012 May 17. [Epub ahead of print]
Genotype impact on long-term virological outcome of chronic hepatitis B virus infection.Malmström S, Eilard A, Larsson SB, Hannoun C, Norkrans G, Lindh M.
Source
Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Abstract
BACKGROUND: The importance of hepatitis B virus (HBV) genotype on the clinical course of chronic HBV infection is not yet clarified.
OBJECTIVES: To investigate genotype impact on long-term virological outcome of chronic HBV infection.
STUDY DESIGN: HBsAg, HBeAg, ALT and HBV DNA levels were determined after a median of 9.2years of follow-up of 124 adults with chronic HBV infection, of whom 33 were HBeAg-positive at inclusion.
RESULTS: HBV DNA levels decreased significantly in patients carrying genotype A (n=28), B (n=21) or D (n=63), but not in those with genotype C infection (n=12). Loss of HBeAg was seen in 44% (4/9) of patients with genotype C, as compared with 92% (22/24) with non-C genotypes. Loss of HBsAg was seen in 36% (10/28) patients with genotype A, 5% (1/21) with B, 0% (0/12) with C, and 11% (7/63) with genotype D.
CONCLUSIONS: HBV DNA levels decreased over time in patients infected with genotypes A, B or D. However, highly active genotype C or D infection often remained highly active, implying a risk for progressive liver damage.

StephenW

参考临床病毒学杂志： 2012五月17日。 [出处提前打印]
长期慢性乙型肝炎病毒感染的病毒学结果的基因型影响。
马尔姆斯特伦小号，一个Eilard，拉尔森SB，Hannoun C，NorkransĞ，林德M.



部传染病Sahlgrenska学院，哥德堡，瑞典哥德堡大学。

摘要

背景：

B型肝炎病毒（HBV）基因型对慢性乙肝病毒感染的临床过程中的重要性尚未澄清。
目的：

调查基因型的影响，长期的慢性乙肝病毒感染的病毒学结果。
研究设计：

测定乙肝表面抗原，e抗原，ALT和HBV DNA水平中位数的124例慢性乙肝病毒感染的成人后续9.2年后，其中33例HBeAg阳性在列入。
结果：

携带基因型的患者HBV DNA水平显着下降，A组（n= 28），乙（N= 21）或D（N= 63），而不是在C基因型感染者（N =12）。 HBeAg的清除在44％（4/9）与C基因型患者，与92％（22/24）与非C基因型相比。 HBsAg的清除在36％（10/28）A基因型病人，与B的5％（1/21），0％（0/12）与C基因型, 11％（7/63）D基因型.
结论：

HBV DNA水平降低患者感染基因型，B或D。然而，高度活跃的基因型C或D感染的时间，经常保持高度活跃，这意味着一个渐进的肝功能损害的风险。

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