Long-term anti-HBs antibody persistence and immune memory in children and adoles

StephenW

Hum Vaccin Immunother. 2012 Jun 1;8(6). [Epub ahead of print]
Long-term anti-HBs antibody persistence and immune memory in children and adolescents who received routine childhood hepatitis B vaccination.Behre U, Bleckmann G, Crasta PD, Leyssen M, Messier M, Marie Jacquet J, Hardt K.
SourcePediatric Practice, Kehl, Baden-Württemberg, Germany.

AbstractPurpose: This paper presents data from two studies that evaluated 5-year and 10-year persistence of antibodies against hepatitis B (HBV) surface antigen (anti-HBs) and immune response to an HBV vaccine challenge in children and adolescents who had received three doses of a HBV vaccine in infancy as part of routine clinical practice [NCT00519649/ NCT00984139].
Results: Anti-HBs antibody concentrations ³ 10mIU/ml persisted in 83.3% (95% confidence interval [CI]: 78.5-87.5) and 78.3% (95% CI: 73.1-83.0) of subjects aged 7-8 years and 12-13 years, respectively 5-10 years after infant vaccination. One month post-challenge dose, 98.2% (95% CI: 95.9-99.4) and 93.7% (95% CI: 90.2-96.2) of subjects in the two age groups, respectively had anti-HBs antibody concentrations ³ 100mIU/ml. Overall, 99.6% (95% CI: 98-100) and 97.2% (95% CI: 94.5-98.8) of subjects aged 7-8 years and 12-13 years mounted an anamnestic response to the HBV challenge dose, which was well-tolerated.
Methods: Healthy children aged 7-8 years and adolescents aged 12-13 years received three doses of a monovalent pediatric HBV vaccine (10µg of HBsAg) before 18 months of age. Serum samples collected before and one month post-HBV vaccine challenge dose were tested for anti-HBs antibody concentrations. Safety assessments were made for the HBV vaccine challenge dose.
Conclusions: A three-dose childhood HBV immunization regimen induced persistence of antibodies against HBV infection for 10 years, up to adolescence. This vaccination regimen also conferred long-term immune memory against HBV as evidenced by the strong anamnestic response to the HBV vaccine challenge, despite waning anti-HBs antibody levels.

StephenW

坎疫苗免疫Immunother。 2012年6月1日，8（6）。 [出处提前打印]
长期抗-HBs抗体在儿童常规接种乙肝疫苗的儿童和青少年的持久性和免疫记忆。
贝里多贝尔ü玛丽·雅凯，ĞBLECKMANN，Crasta的PD，Leyssen梅西耶中号，J，哈特K。
源

儿科实践，凯尔，巴登 - 符腾堡州，德国。
抽象

目的：本文提出了两个研究，评估对乙肝病毒（HBV）表面抗原（抗-HBs）和免疫反应，收到了三个儿童和青少年的乙肝疫苗的挑战5年和10年的抗体持久性的数据剂量乙肝疫苗作为常规的临床实践[NCT00519649 / NCT00984139]在婴儿期。
结果：抗-HBs抗体浓度10mIU/ml立方米坚持在83.3％（95％信心区间[CI]为78.5-87.5）和78.3％（95％CI：73.1-83.0）7-8岁和12岁的科目 - 13年，分别为5-10年后，婴儿接种疫苗。一个月后的挑战剂量，98.2％（95％CI：95.9-99.4）和93.7％（95％CI：90.2-96.2）分别在两个年龄组的受试者，有抗-HBs抗体浓度立方米100mIU/ml。总体而言，99.6％（95％CI：98-100）和97.2％（95％CI：94.5-98.8）受试者年龄在7-8岁和12-13岁登上回忆应答HBV挑战剂量，这是很好耐受性。
方法：年龄为7-8年，年龄在12-13岁的青少年的健康儿童接受三剂单价儿童乙肝疫苗（10μg的乙肝表面抗原）前18个月的年龄。前血清标本收集和乙肝疫苗后1个月的挑战剂量的抗-HBs抗体浓度测试。乙肝疫苗的挑战剂量进行了安全评估。
结论：三个剂量的儿童乙肝免疫疗法引起的持久性抗体，对乙肝病毒感染了10年，到青春期。该疫苗接种方案还赋予尽管减弱抗-HBs抗体水平对乙肝病毒强回忆应答的乙肝疫苗的挑战证明，长期的免疫记忆。

咬牙硬挺

还需要重复打疫苗吗

StephenW

回复 咬牙硬挺 的帖子

如果我们有普遍接种(universal vaccination)。我不认为这将是必要的。