Experimental transmission of hepatitis B virus by tears using mice with chimeric

StephenW

J Infect Dis. 2012 Apr 16. [Epub ahead of print]
Tears from children with chronic hepatitis B virus infection are infectious vehicles of hepatitis B virus. Experimental transmission of hepatitis B virus by tears using mice with chimeric human livers.Komatsu H, Inui A, Sogo T, Tateno A, Shimokawa R, Fujisawa T.
SourceDivision of Hepatology and Gastroenterology, Department of Pediatrics, Eastern Yokohama Hospital.

AbstractBackground
Body fluids from hepatitis B virus (HBV) carriers such as saliva, urine, sweat, and tears, are potential sources of HBV transmission.
Methods
Thirty-nine children and 8 adults who were chronically infected with HBV were enrolled. Real-time PCR was used for the quantification of HBV DNA.ResultsHBV DNA was detected in 73.7% (14/19) of urine samples, 86.8% (33/38) of saliva samples, 100% (11/11) of tear samples and 100% (9/9) of sweat samples. The levels of HBV DNA levels in the urine, saliva, tears, and sweat (mean ± SD) were 4.3 ± 1.1 log copies/mL, 5.9 ± 1.2 log copies/mL, 6.2 ± 0.7 log copies/mL, and 5.2 ± 0.6 log copies/mL, respectively. A statistically significant correlation was observed between HBV DNA in serum and that in saliva/tears (r = 0.88, p <0.001). Tears from a child were injected intravenously into two human hepatocyte-transplanted chimeric mice. One week after inoculation, both chimeric mice became positive for serum HBV DNA.
Conclusions
The levels of HBV DNA in tears from young children were high. Tears were confirmed to be infectious using the chimeric mice. Strict precautions should be taken against direct contact with body fluids from HBV carriers with highly viremia.

PMID:22508939 [PubMed - as supplied by publisher]

StephenW

传染病杂志。 2012年4月16日。 [出处提前打印]
慢性乙型肝炎病毒感染的儿童的眼泪是B型肝炎病毒感染的传输的代表。乙肝病毒传播的实验用小鼠嵌合肝的眼泪。
小松H，干友彦一个，崇光ţ，立野一，下川ŕ，藤泽T.
源

东部横滨医院消化内科，儿科，肝病和司。
抽象

背景
从B型肝炎病毒（HBV）携带者，如唾液，尿液，汗水和泪水的体液，是乙肝病毒传播的潜在来源。
方法
三十九名儿童和8名成人慢性乙型肝炎病毒感染人被录取。实时PCR定量乙肝病毒DNA.ResultsHBV DNA检测尿液样本的73.7％（14/19），86.8％的唾液样本（33/38），100％（11/11）撕裂样本汗液的样本和100％（9/9）。 HBV DNA水平在尿液，唾液，眼泪和汗水的水平（平均值±SD）分别为4.3±1.1log拷贝/ ml，5.9±1.2日志拷贝/ ml，6.2±0.7log拷贝/ ml，5.2±0.6log拷贝/毫升，分别。观察血清中HBV DNA之间有统计学显着相关性和唾液中/眼泪（R = 0.88，P <0.001）。两个人肝细胞移植嵌合体小鼠静脉注射到一个孩子的眼泪。接种后一个星期，这两个嵌合体小鼠血清HBV DNA阳性。
结论
泪水从幼童的HBV DNA水平是很高的。眼泪被证实是传染病的嵌合体小鼠。高度血症的乙肝病毒携带者与体液直接接触，应采取严格的预防措施。

咬牙硬挺

这不是加重了乙肝歧视吗

StephenW

回复 咬牙硬挺 的帖子

是。所有儿童接种疫苗是非常重要的.