CHILDHOOD OBESITY LINKED TO INCREASED RISK OF HEPATOCELLULAR CARCINOMA IN ADULTH

StephenW

CHILDHOOD OBESITY LINKED TO INCREASED RISK OF HEPATOCELLULAR CARCINOMA IN ADULTHOOD

Source: <http://multivu.prnewswire.com/mnr/prne/easl/53808/>

Barcelona, Spain, 19 April 2012 /PRNewswire/ - Childhood obesity is a widespread global epidemic and in parallel with non-alcoholic fatty liver disease (NAFLD)2 is now the leading cause of liver disease among children. New data presented today at the International Liver CongressTM 2012 furthers this concern by showing that childhood obesity is positively linked with developing hepatocellular carcinoma (HCC) the most common form of liver cancer in adulthood. 4

The Danish study monitored birth weight and BMI at school age of 165,540 men and 160,883 women born between 1930 and 1989. The study authors calculated and compared the risk of developing HCC from the 252 participants that had developed HCC at follow-up. At age 7 the risk of developing HCC increased by 1.12 per unit of increase in BMI; however, at age 13 this risk increased to 1.25. Therefore, as units of BMI increased into adulthood, so did the risk of developing HCC. This was consistently similar across the sexes and ages.

EASL Scientific Committee Member Dr. Frank Lammert commented: "Childhood obesity not only leads to the development of many adverse metabolic conditions, such as Type 2 Diabetes and heart disease, but also fatty liver disease, which may subsequently result in liver cancer. The importance of maintaining a healthy childhood BMI cannot be underestimated. These alarming study results point to a potential correlation between childhood obesity and development of liver cancer in adulthood."

Other factors in the development of liver cancer include alcoholic conditions, infection by hepatitis B and C and other liver diseases.5 Results did not change when participants with these co-morbidities were removed from the study, indicating that childhood obesity was the major factor in the development of HCC. Only around 10-20% of liver cancers can be removed completely with surgery and if this is not successful the disease is usually fatal within 3-6 months.3 Therefore prevention is the best protection against the development of liver cancer.

This study was funded by and carried out as part of the FLIP (Fatty Liver Inhibition of Progression) consortia, built around practising clinical hepatologists, basic scientists and two industrial partners who focus on research into the underlying mechanisms and management of patients with NAFLD. The aim of the FLIP project is to understand and prevent the progression of NAFLD into more severe conditions, such as cirrhosis and hepatocellular carcinoma. The project is supported by the European Commission through the Seventh Framework Programme for Research and Development and has been running since January 1st 2010.

StephenW

儿童肥胖与在成年后增加肝癌的风险

来源：<http://multivu.prnewswire.com/mnr/prne/easl/53808/&gt;

西班牙巴塞罗那，2012年4月19日/新华美通/  - 儿童肥胖是一个广泛的全球流行，在并行与非酒精性脂肪肝病（NAFLD）2现在是肝脏疾病的儿童的首要原因。今天在国际肝脏CongressTM 2012年进一步加强了这种担忧，表明儿童肥胖的新的数据正与发展肝细胞癌（HCC）在成年后的肝癌最常见的形式。 4

丹麦研究监测165540男性和160883女性在1930年和1989年之间出生的在校年龄的出生体重和BMI。计算和比较研究作者发展中国家从252参加了后续发展的肝癌肝癌的风险。在7岁的肝癌的风险增加1.12每单位体重的增加，但是，这种风险在13岁上升到1.25。因此，为单位的BMI上升到成年，所以没有肝癌的风险。这是一致的性别和年龄相似。

欧洲肝病学会科学委员会委员弗兰克博士拉默特说：“儿童肥胖不仅导致许多不良的代谢条件，如2型糖尿病和心脏疾病，发展，而且脂肪肝，随后可能导致肝癌的重要性。 BMI保持一个健康的童年不能被低估。这些惊人的研究结果指出，儿童在成年后肥胖和肝癌的发展之间的潜在相关。“

在肝癌的发展的其他因素包括酒精的情况下，感染乙型和丙型肝炎和其他肝脏diseases.5结果没有改变时，这些合并症的参与者，从研究中撤走，这表明，儿童肥胖的主要因素肝癌的发展。可以完全去除大约只有10-20％的肝癌手术，如果没有成功，这是这种疾病通常是致命的，因此在3-6 months.3内预防是最好的保护，对肝癌的发展。

这项研究由翻盖（抑制脂肪肝的进展）财团进行，围绕建立执业临床肝病，基本科学家和两个集中到研究NAFLD患者的基本机制和管理的工业合作伙伴。翻转项目的目的是了解和防止更严厉的条件，如肝硬化和肝癌，脂肪肝的进展。该项目是由欧盟委员会支持通过第七框架计划的研究和开发，并已自2010年1月1日起执行。