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Compend Contin Educ Dent. 2012 Mar;33(3):174-6, 178; quiz 180, 182.
Saliva as a tool in the detection of hepatitis B surface antigen in patients.Arora G, Sheikh S, Pallagatti S, Singh B, Singh VA, Singh R.
SourceDepartment of Oral Medicine and Radiology, MNDAV Dental College and Hospital, Tatul, Solan, Himachal Pradesh, India.
AbstractViral hepatitis is one of the world's most common viral illnesses. Hepatitis B virus infection is a global health problem, and its importance in dentistry is well recognized. The role of saliva in the transmission of hepatitis B makes dentists and dental personnel particularly vulnerable to hepatitis B infection. The objective of this study was to predict the efficacy of saliva as a tool for the detection of hepatitis B surface antigen (HBsAg), which is the hallmark of the infection. The study group comprised 70 patients, 35 of whom were known to be hepatitis B infection seropositive (test group) and the remaining 35 who did not have hepatitis B (control group). All of the subjects were tested with enzyme-linked immunosorbant assay. Of the 35 seropositive subjects, HBsAg was detected in the saliva samples of 26 subjects. The sensitivity and specificity of saliva as a diagnostic tool for detecting HBsAg antigen in this study was 74.29% and 100%, respectively. Because of its noninvasive nature, saliva can be effectively used for large-scale Hepatitis B virus detection.
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