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Viruses recruited to kill tumors
http://www.nytimes.com/2012/03/20/health/research/viruses-are-recruited-and-flipped-as-cancer-killers.html?_r=2
In 1951, a 4-year-old boy with leukemia contracted chickenpox. His liver
and spleen, swollen by the cancer, soon returned to normal, and his
elevated blood cell count fell to that of a healthy child. His doctors
at the Laboratory of Experimental Oncology in San Francisco were
thrilled by his sudden remission, but the blessing was short-lived.
After one month, his leukemia returned and progressed rapidly until the
child's death. [This case sparked interest in using viruses to attack
cancer tumours.] Today, several potential cancer-fighting viruses are in
trials, including two in Phase 3 trials. An engineered form of vaccinia
- the viral agent that helped eradicate smallpox - is being tested
against advanced liver cancer, the third leading cause of cancer deaths
globally. In a recent trial, survival for patients treated with high
doses of the virus, called JX-594, doubled to 14 months from 7, compared
with that of patients treated with low doses. "To see that kind of
response in a randomized trial is simply unheard of," said Tony Reid,
the director of clinical investigation at the Moores Cancer Center of
the University of California, San Diego, who has no financial ties to
the virus's manufacturer.
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发表于 2012-3-31 11:18
