Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg se

9病成医

除了多花钱以外,应该没有多大坏处.

V友

两种不同作用的药物强强联合治疗，思路不错，如恩替与派罗欣，或替诺与派罗欣，不知有没有医院在做

StephenW

回复 V友 的帖子

Many clinical trials are being planned (list supplied by European friend, 4est).
Clinical trials:
1. Korea
Efficacy Study of Sequential Therapy of Peginterferon Alfa-2a Following Entecavir in Patient With Chronic Hepatitis B. (POTENT)
http://clinicaltrials.gov/ct2/show/NCT01220596?term=interferon&recr=Open&cond=Hepatitis+B&rank=8
2. Thailand
Pegylated Interferon Alpha-2b Monotherapy Versus Combination With Entecavir in HBeAg-negative Chronic Hepatitis B
http://clinicaltrials.gov/ct2/show/NCT01243281?term=interferon&recr=Open&cond=Hepatitis+B&rank=11
3. USA
Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B (HBRN)
http://clinicaltrials.gov/ct2/show/NCT01369212?term=interferon&recr=Open&cond=Hepatitis+B&rank=15
4. Taiwan
Pegasys Plus Entecavir Versus Entecavir Alone for Hepatitis Be Antigen-Positive Chronic Hepatitis B
http://clinicaltrials.gov/ct2/show/NCT00597259?term=interferon&recr=Open&cond=Hepatitis+B&rank=24
5. Germany
Peg-interferon ADDed to an Ongoing Nucleos(t)Ide Based Treatment in Patients With Chronic Hepatitis B to Induce Decrease of HBs-Antigen (PADD-ON)
http://clinicaltrials.gov/ct2/show/NCT01524679
许多临床试验正在计划中（欧洲的朋友，4est提供的名单）。
临床试验：
1。韩国
聚乙二醇干扰素α-2a的以下恩替卡韦序贯疗法治疗慢性乙型肝炎（有力）患者的疗效研究
http://clinicaltrials.gov/ct2/show/NCT01220596?term=interferon&recr=Open&cond=Hepatitis+B&rank=8
2。泰国
聚乙二醇干扰素α-2b干扰素单药治疗与结合恩替卡韦在HBeAg阴性慢性乙型肝炎的
http://clinicaltrials.gov/ct2/show/NCT01243281?term=interferon&recr=Open&cond=Hepatitis+B&rank=11
3。美国
聚乙二醇化干扰素α-2a联合治疗和泰诺福韦对战替诺福韦单药治疗慢性乙型肝炎（HBRN）
http://clinicaltrials.gov/ct2/show/NCT01369212?term=interferon&recr=Open&cond=Hepatitis+B&rank=15
4。台湾
PEGASYS加替卡韦对恩替卡韦独自肝炎抗原阳性的慢性乙型肝炎
http://clinicaltrials.gov/ct2/show/NCT00597259?term=interferon&recr=Open&cond=Hepatitis+B&rank=24
5。德国
PEG-干扰素加入正在进行的核苷（酸）在基于IDE的治疗慢性乙型肝炎患者的乙型肝炎表面抗原诱导的减少（炼油厂上周的炼油-ON）
http://clinicaltrials.gov/ct2/show/NCT01524679

三国杀

回复 StephenW 的帖子

重医附二现在主研的一个课题就是这样
不过，用的是替诺以外的其他药

也是要先到检测下线，再上长效干扰素