在慢性HBV感染的患者中，肝内干扰素信号激活前与干扰素α

StephenW

                          在慢性HBV感染的患者中，肝内干扰素信号激活前与干扰素α治疗无应答相关
                          Preactivation of the interferon signalling in liver is correlated with nonresponse to interferon alpha therapy in patients chronically infected with hepatitis B virus                   

                           来自:J VIRAL HEPATITIS(2012-02-01)

                              

              作者：                               C. Xiao, B. Qin, L. Chen, H. Liu, Y. Zhu, X. Lu                           
                PMID：                                                           暂无                                                                          

                   Interferon alpha (IFN-) therapy is widely used to treat patients with chronic hepatitis B (CHB) but the sustained response rate is low, and the molecular mechanisms for the ineffectiveness of IFN- treatments are not known. We screened differentially expressed genes between responders (Rs) and nonresponders (NRs) in patients with CHB treated with IFN- to explore the molecular basis for treatment failure. Expression profiling was performed on percutaneous needle liver biopsy specimens taken before therapy. Gene expression levels were compared between seven patients who did not respond to therapy (NR) and six who did respond (R). Gene ontology category and KEGG pathway were analysed for differentially expressed genes, and the selected differentially expressed genes were confirmed using real-time polymerase chain reaction. We identified 3592 genes whose expression levels differed significantly between all Rs and NRs (P < 0.05); many of these genes are IFN-stimulated genes (ISGs) and immune-related genes. The ISGs were more highly expressed, while immune-related genes were inhibited in NRs before IFN- treatment. Two ISGs (CEB1 and USP18) that are linked in an IFN inhibitory pathway are highly expressed in NRs, and a potential antiviral gene ISG20 was inhibited in NRs, suggesting a possible rationale for treatment nonresponse. Patients who do or do not respond to IFN have different liver gene expression profiles before IFN- treatment. Preactivation of the IFN signalling pathway leading to the increased expression of inhibitory ISGs and inhibition of immune response in the pretreatment livers was associated with treatment failure.            

StephenW

在慢性乙肝病毒感染的患者大全 - 宜配网，肝内干扰素信号激活前相关的例句干扰素α的治疗。无应答相关
肝干扰素信号的预激活无应答与α-干扰素治​​疗慢性乙型肝炎病毒感染的患者

J病毒性肝炎（2012年2月1日）

返回本期列表作者：L.陈，萧三，二秦H.刘，华朱，十路
关键词：暂无
α-干扰素（IFN-α]）疗法被广泛用于治疗慢性乙型肝炎（CHB），但持续应答率是低的患者，并为无效的分子机制干扰素-α]治疗不为人所知。我们在治疗慢性乙型肝炎患者的反应（RS）和无反应（NRS）之间的差异表达基因筛选IFN-α]探讨治疗失败的分子基础。表达谱进行穿刺肝活检治疗前采取标本。谁没有回应治疗（NR）和响应（R）的6名病人之间的基因表达水平进行了比较。基因本体类和KEGG通路的差异表达的基因进行了分析，并采用实时聚合酶链反应的差异表达选择​​的基因被证实。我们确定了3592个基因，其表达水平的所有卢比和卢比（P <0.01）显着差异，其中许多基因是干扰素刺激基因（ISGs）和免疫相关的基因。 ISGs被更多的高表达，而抑制免疫相关基因在干扰素-α治疗前的自然保护区。两个ISGs（CEB1和USP18）在干扰素抑制通路相连的高效表达，在自然保护区，在自然保护区的一个潜在的抗病毒基因ISG20被抑制，提示可能为治疗无应答的理由。干扰素-α治疗前，谁做或不响应干扰素的患者有不同的肝基因表达谱。预激活干扰素信号通路，抑制ISGs和抑制免疫反应中的预处理肝脏的表达增加，与治疗失败。

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