Test for liver damage uses blood sample instead of biopsy

StephenW

                                                        http://www.wired.co.uk/news/archive/2012-01/30/siemens-liver-test
Science               Test for liver damage uses blood sample instead of biopsy                    By Olivia Solon
                30 January 12
   
                                                                                    

Siemens has developed a new test for diagnosing liver damage that requires only a bloodsample instead of a biopsy.
The Enhanced Liver Fibrosis test is not only less invasive andpainful than the biopsy -- which involves the removal of a smallamount of liver tissue --  but it also takes just an hourinstead of a week. The test was developed by Siemens Healthcare incollaboration with University College London.
Liver fibrosis is the scarring of the liver tissue associatedwith chronic liver damage and can be caused by alcoholism, fattyliver disease or viralhepatitis. It can lead to cirrhosis or cancer of the liver over the long term.
The ELF Test looks for three blood serum biomarkers: hyaluronicacid, procollagen III N-terminal propeptide, and the tissueinhibitor metalloproteinase. These biomarkers are involved in theformation of fibrosis. In the test, reagents react with thebiomarkers and generate light in the process. The more lightgenerated, the more biomarkers are present.
The test then uses an algorithm to convert the results of thethree biomarkers into a score that indicates the degree of fibrosis--slight, moderate or serious. Patients with slight or moderatefibrosis are unlikely to display any other symptoms, so doctors canintervene and prevent further liver damage.
The ELF Test has been in development since 1997, when a group ofinvestigators led by Professor Michael Arthur embarked on a projectto identify serum markers of liver fibrosis. The project recruitedmore than 1,000 patients who were having a liver biopsy and tookblood samples at the same time. This process helped to identify thethree relevant markers.




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StephenW

科学
肝功能损害的测试使用血液样本，而不是活检
到奥利维亚梭伦
1月30日12日


西门子公司已开发出一种新的测试，只需要一个血液样本，而不是活检对肝功能损害的诊断。

增强肝纤维化的测试，不仅创伤小，痛苦比活检 - 其中包括少量的肝组织的去除 - 但它也需要一个星期的短短一个小时内，而不是。西门子医疗在与英国伦敦大学学院合作开发的测试。

肝纤维化是与慢性肝损伤相关的肝组织疤痕，可引起酒精中毒，脂肪肝疾病或病毒性肝炎。它可以导致长期肝硬化或肝癌。

ELF测试看起来血清生物标志物：透明质酸，胶原III N -端肽，并组织抑制剂金属蛋白酶。这些生物标志物是参与肝纤维化的形成。在测试中，试剂与生物标志物的反应，并在这个过程中产生的光。产生的更多的光，更多的生物标志物的存在。

测试，然后使用一种算法来转换成一个分数，表明纤维化程度的生物标志物的结果 - 轻度，中度或严重。轻微或中度纤维化患者不会显示任何其他症状，所以医生可以进行干预，防止进一步肝损害。

一直在发展，自1997年以来，当迈克尔亚瑟教授领导的调查小组展开一个项目，以确定肝纤维化血清标志物的ELF测试。该项目招募超过1000名患者有肝活检，并参加了在同一时间的血液样本。这个过程有助于确定三个相关的标记。

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