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本帖最后由 风雨不动 于 2012-4-14 14:54 编辑
Hepatology. 2012 Jan 23. doi: 10.1002/hep.25608.
Source: http://www.ncbi.nlm.nih.gov/pubmed/22271421
MxA inhibits hepatitis B virus replication by interaction with core protein
HBcAg. Li N, Zhang L, Chen L, Feng W, Xu Y, Chen F, Liu X, Chen Z, Liu W.
SourceDepartment of Biochemistry and Molecular Biology, Program in
Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou,
Zhejiang 310058, China. Abstract Human MxA, an interferon-inducible
cytoplasmic dynamin-like GTPase, possesses antiviral activity against
multiple RNA viruses. Recently, MxA has also been demonstrated to have
activity against the hepatitis B virus (HBV), a well-known DNA virus
responsible for acute and chronic liver disease in humans. Here, we
investigated the molecular mechanism for the anti-HBV activity of MxA. Our
results demonstrated that in HepG2.2.15 cells, MxA GTPase-independently
suppressed the production of hepatitis B surface antigen (HBsAg) and HBV
DNA without changing the level of hepatitis B core antigen (HBcAg) and the
distribution of HBV mRNA. MxA significantly reduced the level of the
encapsidated pregenomic RNA (pgRNA). Through its central interactive
domain, MxA interacted with HBcAg causing accumulation of the proteins in
perinuclear compartments. MxA-HBcAg interaction significantly affected the
dynamics of HBcAg by immobilizing HBcAg in the perinuclear structures.
CONCLUSION: MxA displays antiviral activity against HBV involving a
mechanism of MxA-HBcAg interaction which may interfere with core particle
formation. (HEPATOLOGY 2012.).
[Notes by Christine M. Kukka , editor of hbvadovcate]
Hi, These definitions are is still vague, but I hope they help... reading
between the lines, it seems it works like an interferon.... Definition 1.
MxA is a GTPase encoded by an interferon-activated human gene which
inhibits the multiplication of several RNA viruses. Definition 2. The
interferon-induced human MxA protein belongs to the dynamin superfamily of
large GTPases and accumulates in the cytoplasm. MxA is a key component of
the innate antiviral response and has previously been shown to inhibit
several viruses with single-stranded RNA genomes of both polarities and a
DNA virus. In addition, MxA also targets two double-stranded RNA viruses,
Infectious bursal disease virus and a mammalian reovirus as shown in this
study. Thus, the antiviral spectrum of human MxA is broader than hitherto
suspected. Interestingly, virus growth was not affected in cells expressing
MxA(E645R), a mutant form of MxA that showed antiviral activity against
orthomyxoviruses.
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发表于 2012-1-31 07:42