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本帖最后由 风雨不动 于 2012-4-14 14:54 编辑
J Huazhong Univ Sci Technolog Med Sci. 2012 Feb;32(1):69-74.
Source: http://www.ncbi.nlm.nih.gov/pubmed/22282248
Noninvasive measurement of liver fibrosis by transient elastography and
influencing factors in patients with chronic hepatitis B-A single center
retrospective study of 466 patients. Ding H, Wu T, Ma K, Wang X, Wu Z, Guo
W, Qi J, Ning Q. SourceDepartment of Infectious Diseases, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology,
Wuhan, 430030, China, [email protected].
Abstract
The noninvasive measurement of liver stiffness (LS) was evaluated by
transient elastography (FibroScan) and the possible influencing factors
from the patients' clinical situations including age, gender, liver
inflammation represented by alanine transaminase (ALT) and total billirubin
(TBIL) level, HBV replication (HBV DNA loads), portal vein pressure
(portal vessel diameter, PVD), splenic thickness (SPT) and body mass index
(BMI) were analyzed in patients with chronic hepatitis B (CHB). A total of
466 patients including 31 patients with acute-on-chronic liver failure
(ACLF), and 435 patients with chronic hepatitis B (CHB) among which 82
patients were diagnosed with liver cirrhosis (LC) by clinical
manifestations and liver B-type ultrasonic inspection were enrolled at
Tongji Hospital from April to December 2009. LS was measured by a FibroScan
device (EchoSens, France). Simultaneously, ALT and TBIL levels, HBV DNA
loads, PVD, SPT and BMI in all patients were also tested. Forty-one healthy
volunteers served as controls. The values of LS were correlated positively
with ages of CHB patients and significantly higher in males than in
females. In patients with BMI>28 kg/m(2) (obesity) and abnormal levels of
ALT and TBIL, LS values were significantly increased as compared with those
having normal levels of ALT and TBIL. The patients with ACLF had the
highest LS value. Furthermore, LS values in the patients with LC were
significantly higher than those in patients without LC. It is concluded
that noninvasive measurement of liver fibrosis by FibroScan provides an
alternative method to evaluate liver fibrosis of patients with CHB. In
order to properly illustrate the stiffness value taken by transient
elastography, patients' gender should be taken into consideration and it is
also suggested to avoid possible influencing factors including liver
inflammation (high levels of ALT and TBIL) and obesity (high BMI).
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发表于 2012-1-29 07:48
