Virologic factors associated with failure to passive-active immunoprophylaxis in

StephenW

J Viral Hepat. 2012 Feb;19(2):e18-25. doi:
10.1111/j.1365-2893.2011.01492.x. Epub 2011 Aug 1.
Virologic factors associated with failure to passive-active immunoprophylaxis in infants born
to HBsAg-positive mothers.
Source:http://www.ncbi.nlm.nih.gov/pubmed/22239517
Zou H, Chen Y, Duan Z, Zhang H, Pan C.
Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China Department of Obstetrics and Gynecology, Beijing Youan Hospital, Capital Medical University, Beijing, China
Division of Liver Diseases, Mount Sinai Hospital, Mount Sinai School of
Medicine, New York, NY, USA.
Abstract Summary.  In infants born to hepatitis B surface antigen (HBsAg)-positive mothers, failure after passive-active immunization still occurs. The role of maternal hepatitis B
DNA level and other risk factors in this setting remains unclear. This study retrospectively evaluated virologic and other risk factors associated with immunoprophylaxis failure in infants born to HBsAg-positive mothers. Between January 2007 and March 2010, we reviewed the clinical and virologic tests in 869 mother-infant pairs. All infants received the identical passive-active immunization schedule after birth. The failure infants
(HBsAg positive at 7-12 months of age) were compared to infants who were
HBsAg negative when tested during this time period. Among 869 infants, 27
(3.1%) infants were immunoprophylaxis failures and the other 842 (96.9%)
infants remained HBsAg negative. When mothers' pre-delivery HBV DNA levels
were stratified to <6, 6-6.99, 7-7.99 and >=8 log(10 ) copies/mL, the
corresponding rates of immunoprophylaxis failure were 0%, 3.2% (3/95), 6.7%
(19/282) and 7.6% (5/66), respectively (P < 0.001 for the trend). All
failure infants were born to hepatitis B e antigen (HBeAg)-positive
mothers. Multivariate logistic regression analysis identified maternal HBV
DNA levels [odds ratio (OR) = 1.88, 95% confidence interval (CI):
1.07-3.30] and detectable HBV DNA in the cord blood (OR = 39.67, 95% CI:
14.22-110.64) as independent risk factors for immunoprophylaxis failure.
All failure infants were born to HBeAg-positive mothers with HBV DNA levels
>=6 log(10) copies/mL. The presence of HBV DNA in cord blood predicted
failure to passive-active immunization.




(6.合.彩)足球.篮球...各类投注开户下注

第一投注现金网:招代理年薪10万以上:yyu.cc

StephenW

病毒Hepat。 2012年2月19（2）：E18 - 25。 DOI：
10.1111/j.1365-2893.2011.01492.x。作者2011年8月1日。病毒学因素
与活跃在出生的婴儿被动免疫预防失败
HBsAg阳性母亲的。来源：
http://www.ncbi.nlm.nih.gov/pubmed/22239517邹H，陈宜瑜，段Z，张华，
泛C. SourceArtificial肝中心，北京佑安医院，首都
医科大学，北京，中国妇产科学系，
北京佑安医院，首都医科大学，北京，中国
，西奈山医学院，西奈山医院肝病科
医药，纽约，NY，美国。摘要摘要。在婴儿出生
乙肝表面抗原（HBsAg）阳性的母亲，失败之后
被动主动免疫仍发生。产妇B型肝炎的作用
DNA水平，并在此设置的其他风险因素仍不清楚。这
研究回顾性评估的病毒学和其他相关的风险因素
在HBsAg阳性母亲所生的婴儿的免疫预防失败。
2007年1月至2010年3月，我们检讨了临床和病毒学
在869对母婴的测试。所有婴儿收到相同
出生后的被动免疫计划。失败的婴儿
（乙肝表面抗原在7-12个月的年龄呈阳性）的婴儿相比，谁是
HBsAg阴性，在这段时间内进行测试时。其中869例婴儿，27
（3.1％）的婴儿免疫预防失败和其他842人（96.9％）
婴儿保持HBsAg阴性。当母亲交付前HBV DNA水平
分层<6，6-6.99 7-7.99, >= 8 log（10）拷贝/ ml，
相应的免疫预防失败率分别为0％，3.2％（3 / 95），6.7％
（二百八十二分之一十九）和7.6％（5 / 66），趋势（P <0.001）。所有
失败的婴儿出生乙肝e抗原（HBeAg）阳性
母亲。多因素Logistic回归分析确定孕产妇乙肝病毒
DNA水平[比值比（OR）= 1.88，95％可信区间（CI）：
1.07-3.30]和脐带血检测乙肝病毒DNA（OR = 39.67，95％CI：
14.22-110.64）作为免疫预防失败的独立危险因素。
所有不合格婴儿HBV DNA水平，HBeAg阳性母亲所生
>=6log（10）拷贝/ ml。脐血中的HBV DNA存在预测
被动主动免疫失败。

咬牙硬挺

马克主义