The characteristics of the synonymous codon usage in hepatitis B virus and the e

StephenW

http://7thspace.com/headlines/402242/the_characteristics_of_the_synonymous_codon_usage_in_hepatitis_b_virus_and_the_effects_of_host_on_the_virus_in_codon_usage_pattern.html
The characteristics of the synonymous codon usage in hepatitis B virus and the effects of host on the virus in codon usage pattern
  Hepatitis B virus (HBV) infection is one of the main human health problem and causes a large-scale of patients chronic infection worldwide.. As the replication of HBV depends on its host cell system, codon usage pattern for the viral gene might be susceptible to two main selections, namely mutation pressure and translation selection.

In this case, a deeper investigation between HBV evolution and host adaptive response might assist control this disease.
Result: Relative synonymous codon usage (RSCU) values for the whole HBV coding sequence were studied by Principal component analysis (PCA). The characteristics of the synonymous codon usage patterns, nucleotide contents and the comparison between ENC values of the whole HBV coding sequence indicated that the interaction between virus mutation pressure and host translation selection exists in the processes of HBV evolution.

The synonymous codon usage pattern of HBV is a mixture of coincidence and antagonism to that of host cell. But the difference of genetic characteristic of HBV failed to be observed to its different epidemic areas or subtypes, suggesting that geographic factor is limited to influence the evolution of this virus, while genetic characteristic based on HBV genotypes could be divided into three groups, namely (i) genotyps A and E, (ii) genotype B, (iii) genotypes C, D and G.

Conclusion: Codon usage patterns from PCA for identification of evolutionary trends in HBV provide an alternative approach to understand the evolution of HBV.

Further more, a combined selection of mutation pressure with translation selection on codon usage might shed alight on understanding the evolutionary trends of HBV genotypes.

Author: Ming-ren MaXiao-qin HaHui LingMei-liang WangFang-xin ZhangShang-di ZhangGe LiWei Yan
Credits/Source: Virology Journal 2011, 8:544

StephenW

在B型肝炎病毒的同义密码子使用的特点和影响的主机上的密码子使用模式病毒
乙型肝炎病毒（HBV）感染是主要的人类健康问题之一，并导致世界范围内一个大型的患者的慢性感染..由于HBV复制上取决于其宿主细胞系统，病毒基因的密码子使用模式可能会受到两个主要选择，即突变压力和翻译选择。

在这种情况下，乙肝病毒的演变和宿主适应性反应之间更深入的调查可能有助于控制这种疾病。
结果：相对同义密码子的使用（RSCU）HBV全编码序列的值进行了研究，通过主成分分析（PCA）。同义密码子使用模式，核苷酸内容和整个HBV编码序列的ENC值之间的比较的特点表明，在乙肝病毒进化的过程中存在病毒变异的压力和主机翻译选择之间的相互作用。

乙肝病毒的同义密码子使用模式是一种巧合和对抗宿主细胞的混合物。但未能观察到其不同的疫区或亚型乙肝病毒遗传特性的差异，表明地理因素是有限的影响，这种病毒的演变，同时根据HBV基因型的遗传特征可以分为三类，即（ I）genotyps A和E，（二）B型，（三）基因型C，D和G。

结论：识别乙肝病毒的进化趋势从PCA密码子使用模式提供了一种替代方法，了解乙肝病毒的演变。

另外，组合选择的突变与翻译上的密码子使用选择的压力可能棚上下车了解HBV基因型的进化趋势。

作者：秦铭仁MaXiao HaHui陈灵梅良网万方新ZhangShang- DI ZhangGe杨利伟颜
积分/来源：病毒学杂志2011，8:544