HBV Journal Review[Nov] Lab Tests Unable to Detect Hepatitis B in Patients Infec

StephenW

Lab Tests Unable  to Detect Hepatitis B in Patients Infected with Genotype G

                   Researchers, studying the rare hepatitis B  virus (HBV) strain called genotype G, found that current lab tests are unable  to detect hepatitis B in patients with this genotype, according to their report  published in the November issue of the Journal of Viral Hepatitis.
                  HBV Genotype G infects fewer than 1% of people with  hepatitis B worldwide and is found primarily in Europe and the U.S. Because of  its unique molecular make-up, HBV genotype G can replicate without producing  the hepatitis B surface antigen (HBsAg) or the hepatitis B “e” antigen  (HBeAg)—two antigens that are required by every other HBV genotype to  reproduce.
                  Lab tests used to detect HBV infection in people and  blood donors specifically look for HBsAg. Additionally, people with HBV  Genotype G often have low levels of HBV DNA (viral load), which also escape  detection.
                  The threat of an undetectable HBV genotype is just  now coming to light because most people with HBV genotype G are also coinfected  with HBV genotype A, which does produce HBsAg and HBeAg when reproducing, so  researchers assumed genotype G would also generate those antigens during its  reproductive cycle.
                  But in this recent study, scientists studied blood  samples from a patient who was newly infected with only HBV genotype G  infection. Over the course of his infection, the patient showed the presence of  HBV DNA, and hepatitis core antibodies (which develop after initial exposure to  the virus), but he produced neither surface nor “e” antigens or antibodies.
                  “Our findings demonstrate that HBV genotype G  mono-infection occurs and that routine serology (blood tests are) unsuitable  for its detection,” the researchers wrote.

StephenW

实验室测试无法检测到B型肝炎与基因型摹(G)感染的患者

研究人员，研究发现，目前的实验室测试无法检测这种基因型的患者乙肝，根据他们的报告病毒性肝炎杂志11月号发表的罕见肝炎的乙肝病毒（HBV）的菌株称为基因型摹，。

HBV基因型摹感染全球B型肝炎的人只有不到1％，主要是在欧洲和美国由于其独特的分子使HBV基因型G可以复制​​，不产生乙肝表面抗原（HBsAg）或肝炎乙“E抗原（HBeAg），两个是由每一个其他的基因型重现抗原。

实验室测试中使用的检测人员和献血者的HBV感染，专门研究为乙肝表面抗原。此外，与乙肝病毒基因型摹的人往往有低层次的HBV DNA（病毒载量），这也无所遁形。

检测不到HBV基因型的威胁是刚才未来的光，因为也与HBV基因型A，它不产生HBsAg和HBeAg时，音响的合并感染HBV基因型摹的大多数人，因此，研究人员假定基因型摹也会产生这些抗原在其生殖周期。

但在这最近的一项研究中，科学家们研究从一个只有基因型摹感染新感染的病人的血液样本。在他的感染过程中，患者表现为HBV DNA的存在，和肝炎核心抗体（初次接触病毒后发展），但他制作的既不是表面或“E”的抗原或抗体。

“我们的研究结果表明，HBV基因型摹单感染发生和常规血清学检查（验血）不适合其检测，”研究人员写道。