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- 2011-9-27
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- 2022-11-15
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To: xiegk:
上面很多战友说效果不错,真羡慕,可是我感觉不好,用五年了,花了快十万了吧,不知是本人运气不好还是恩替宣传的过头了,我2006年11月在医生的建议下用这个药,6个月内转阴,肝功正常,可不到一年开始DNA反弹,又坚持了半年,确认是反弹,2009年初做肝穿刺肝受损状况较好,医生就建议停用或加药,我选择了停药,
If your doctor 建议停用 then he is NOT a qualified doctor.
心情沮丧极了,不知如何是好
read this paper:
Hepatitis B Virus Resistance to Nucleos(t)ide Analogues
REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY
GASTROENTEROLOGY 2009;137:1593–1608
LMV resistance: add TDF (add ADV if TDF not
available);
● ADV resistance: it is recommended to switch to TDF
if available AND add a second drug without crossresistance.
If an rtN236T substitution is present, add
LMV, ETV, or LdT or switch to TDF plus emtricitabine.
If an rtA181V/T substitution is present, it is
recommended to add-on ETV or to switch to TDF
plus ETV or TDF plus emtricitabine (as a single
tablet: Truvada);
● LdT resistance: it is recommended to add TDF (or
ADV if TDF is not available);
● ETV resistance: it is recommended to add TDF;
And find another 'qualified' doctor to discuss your treatment plan, with the reference above paper.
Dan |
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