Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

StephenW

http://www.gastrojournal.org/article/S0016-5085%2811%2901228-5/abstract
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can lead to fibrosis and cirrhosis. The latest surveillance report published by the National Institute on Alcohol Abuse and Alcoholism showed that liver cirrhosis was the 12th leading cause of death in the United States, with a total of 29,925 deaths in 2007, 48% of which were alcohol related. The spectrum of ALD includes simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and superimposed hepatocellular carcinoma. Early work on the pathogenesis of the disease focused on ethanol metabolism–associated oxidative stress and glutathione depletion, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate Kupffer cells. We review findings from recent studies that have characterized specific intracellular signaling pathways, transcriptional factors, aspects of innate immunity, chemokines, epigenetic features, microRNAs, and stem cells that are associated with ALD, improving our understanding of its pathogenesis. Despite this progress, no targeted therapies are available. The cornerstone of treatment for alcoholic hepatitis remains as it was 40 years ago: abstinence, nutritional support, and corticosteroids. There is an urgent need to develop new pathophysiology-oriented therapies. Recent translational studies of human samples and animal models have identified promising therapeutic targets.



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StephenW

[谷歌翻译是不是100％准确，仅供参考使用。]

酒精性肝病（ALD）是一个全球慢性肝病的主要病因，并可能导致纤维化和肝硬化。国家酒精滥用和酒精中毒研究所发表的最新监测报告显示，肝硬化是第12次在美国死亡的首要原因，在2007年共有29925人死亡，其中48％的酒精相关。 ALD的范围包括简单的脂肪变性，酒精性肝炎，肝纤维化，肝硬化，和肝癌的叠加。乙醇代谢相关的氧化应激和谷胱甘肽耗竭，蛋氨酸代谢异常，营养不良，内毒素激活枯否细胞的生产主要集中在疾病发病的早期工作。我们回顾从最近的研究结果，有特定的细胞内信号转导通路特点，转录因子，改善方面的先天免疫，趋化因子，表观遗传特征，小分子RNA，并与ALD的相关联的干细胞，其发病机制的认识。尽管取得了这些进步，没有针对性的治疗。酒精性肝炎治疗的基石仍然是因为它是40年前戒酒，营养支持，和皮质类固醇。有一个迫切需要制定新的病理生理为导向的疗法。最近翻译的人体标本和动物模型研究前途的治疗目标已经确定。

huangxujun

  这是 中文跟英文的？   

StephenW

huangxujun 发表于 2011-10-27 01:29
这是 中文跟英文的？

是的，请阅读英文版本，因为翻译英文不是100%准确.