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本帖最后由 风雨不动 于 2012-4-14 14:44 编辑
[This is a Google Translation of the original press release in German]
http://www.helmholtz-muenchen.de/presse-und-medien/pressemitteilungen/pressemitteilungen-2011/pressemitteilung-2011/article/15306/index.html
Fight virus and stimulate the immune system: New treatment for Hepatitis B
Neuherberg, 11.10.2011.
A new treatment option for chronic hepatitis B infection improves the chance of cure hepatitis B. With the help of short pieces of RNA, it is a collaboration of the Helmholtz Center Munich, Technical University of Munich and the University of Bonn succeeded in the stopping the reproduction of the hepatitis B virus and at the same time to stimulate the immune system. The study is published in the prestigious journal Gastroenterology:
Ebert, G et al (2011), 5 'Triphosphorylated small interfering RNAs control replication of hepatitis B virus and to induce interferon response in human liver cells and mice. Gastroenterology 141:696
Prof. Dr. Ulrike Protzer
The team led by Prof. Ulrike Protzer, director of the Institute for Virology, Helmholtz Center Munich and the Technical University of Munich, in collaboration with Dr. Hendrik Poeck, the right of the Isar Hospital in Munich Technical University, and Professor Gunther Hartmann of the University of Bonn a new treatment option for chronic hepatitis B develops. The study published in Gastroenterology describes the use of siRNAs * that have been specifically modified. The designers RNA fragments inhibit the replication of the hepatitis B virus in the body, but have still another function: They stimulate the immune system, this can again be effective in combating the virus.
"Our study shows that the combination of both functions - the inhibition of virus replication and immune stimulation - in a siRNA is significantly more effective than the corresponding mono-functional nucleic acids," says Prof. Ulrike Protzer, director of the study. "We have used this approach for the first time the prospect of the hepatitis B virus infection even with a chronic low back completely remove from the body."
If chronic hepatitis B, although they can develop drugs through controlled but not cured. The infection is approximately 350 million cases worldwide one of the most important viral diseases of humans and can be seen by the high number of cases as a public health problem. The understanding of the pathophysiology of common diseases and the derivation of new targets for diagnosis, therapy and prevention is the goal of the Helmholtz Zentrum München.
For more information
Background
* SiRNA (small interfering ribonucleic acids) are short RNA fragments are leading to that sequence-analog mRNAs degraded and not translated into proteins. Thus, for example, the propagation of a virus can be significantly reduced.
Original Publication: Ebert, G et al (2011), 5 'Triphosphorylated small interfering RNAs control replication of hepatitis B virus and to induce interferon response in human liver cells and mice. Gastroenterology 141:696
Link to the trade publication
The Helmholtz Zentrum München German Research Center for persecuted as health and the environment, the goal of personalized medicine for the diagnosis, therapy and prevention of developing common diseases such as diabetes mellitus and pulmonary disease. There examined the interaction of genetics, environmental factors and lifestyle. The major facility is located in Neuherberg to the north of Munich. The Center employs approximately 1,900 people and is a member of the Helmholtz Association, members of the 17 scientific-technical and medical-biological research centers with approximately 31,000 employees. www.helmholtz-muenchen.de
The Technical University of Munich (TUM) is about 460 professors, 7,500 employees (including the right of the Isar Hospital) and 26,000 students one of the leading technical universities in Europe. It focuses on the engineering sciences, natural sciences, life sciences, medicine and economics. After numerous awards, it was founded in 2006 by the Science and the German Research Foundation elected to a University of Excellence. The university's global network includes an outpost in Singapore. TUM is the model of entrepreneurial university. www.tum.de
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发表于 2011-10-13 15:31
