Serum markers for necroinflammatory坏死性炎血清标志物

StephenW

<http://www.mdlinx.com/infectious-disease/newsl-article.cfm/3749763/ZZ680655367925639220014/?news_id=497&newsdt=092311&subspec_id=130>


Serum markers for necroinflammatory activity in patients with chronic viral
hepatitis and normal or mildly elevated aminotransferase levels

Liver International, 09/23/2011

Cheong JY et al. – The Aspartate aminotransferase(AST) and apolipoprotein
A1 levels were shown to be independent predictors of significant
inflammatory activities in patients with chronic hepatitis B(CHB) and
chronic hepatitis C(CHC) and normal or mildly elevated aminotransferase
levels.

Methods• 227 patients with CHB or CHC with normal or mildly elevated
serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST)
levels (≤60IU/L) were enrolled in this study. • Significant
inflammation was defined as inflammatory grade ≥3 activities using the
Batt-Ludwig scoring system. • Correlation between liver histology and
serum markers of liver inflammation was analysed.

Results

• 48 (21.1%) and eight patients (3.5%) had grade 3 and 4 inflammation
respectively. • Univariate analysis revealed that age, platelet count, and
AST, ALT, γ-glutamyl transpeptidase, alkaline phosphatase, hyaluronic
acid, haptoglobin, apolipoprotein A1 and procollagen III N-terminal peptide
levels were significantly different between the patients with and without
significant inflammation. • There were no significant differences in the
cytokeratin-18 fragment levels between the two groups. • On the basis of
multivariate analysis, the AST and apolipoprotein A1 levels and stage of
fibrosis were highly predictive of significant inflammation. • Using AST
and apolipoprotein cut-off values ≥44IU/L and ≤100ng/ml, respectively,
the presence of significant inflammation was predicted with high
specificity (96.5%) and with a negative predictive value of 76.3%.



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StephenW

慢性病毒性肝炎患者血清标志物为坏死性炎症活动
肝炎和转氨酶水平正常或轻度升高

肝国际，2011年9月23日

昌JY等。 - 谷草转氨酶（AST）和载脂蛋白
A1水平的独立预测因素的显著
慢性乙型肝炎（CHB）患者的炎症活动
慢性丙型肝炎（CHC）和正常或轻度升高的转氨酶
水平。

•227例慢性乙型肝炎或CHC方法与正常或轻度升高
血清谷丙转氨酶（ALT）和谷草转氨酶（AST）
水平（≤60IU/ L），分别参加了这项研究。 •显着
炎症炎症级定义为≥3项活动使用
BATT -路德维希评分系统。 •肝脏组织学和之间的相关性
肝脏炎症反应的血清标志物进行了分析。

结果

•48（21.1％）和8例（3.5％），3级和4炎症
。 •单因素分析显示，年龄，血小板计数，
AST，ALT，γ-谷氨酰转移，碱性磷酸酶，透明质酸
酸，结合珠蛋白，载脂蛋白A1和N -端肽胶原三
水平显着不同的患者与不
显著炎症。 •有没有显著差异
细胞角蛋白18片段水平两组之间。 •在基础
多变量分析，AST和载脂蛋白A1水平和阶段
纤维化是非常显著炎症的预测。 •使用助攻
和载脂蛋白的临界值≥44IU/ L和≤100ng/ml，分别
高预测显著炎症的存在
特异性（96.5％）和带负76.3％的预测值。