GGT is the most reliable predictor of nonresponsiveness to interferon-alpha base

StephenW

http://www.docguide.com/determination-ggt-most-reliable-predictor-nonresponsiveness-interferon-alpha-based-therapy-hcv-type-?hash=c8431e6c&eid=22194&alrhash=2f4244-e14fac0ff7ef1d5b0c78458126191858

The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection; Weich V, Herrmann E, Chung TL, Sarrazin C, Hinrichsen H, Buggisch P, Gerlach T, Klinker H, Spengler U, Bergk A, Zeuzem S, Berg T; Journal of Gastroenterology (Sep 2011)
BACKGROUND: The critical analysis of baseline factors has been found to be useful to predict virologic nonresponse (NR), relapse, or sustained virologic response (SVR) in patients infected with hepatitis C virus (HCV) who receive antiviral therapy. In the present retrospective study we tried to find out whether gamma-glutamyltranspeptidase (GGT) may be one of the baseline factors which are of special predictive power. We analyzed, in patients with different treatment outcomes, the predictive power of established baseline factors either in combination with GGT or by evaluating the predictive value of GGT independently. METHODS: Individual data from 632 patients chronically infected with HCV type 1 (n = 561) or type 2/3 (n = 71) were analyzed. All patients had received their first course of antiviral therapy and were treated with pegylated interferon α-2a or -2b plus ribavirin. RESULTS: In patients with HCV type 1, a multivariate multinomial logistic regression analysis identified low GGT (p < 0.0001), high cholesterol (p < 0.0001), age ≤40 years (p < 0.0001), high alanine aminotransferase (p = 0.0006), low viremia (p = 0.0014), and absence of cirrhosis (p = 0.0164) as independent predictors. While these baseline factors heralded improved virologic response, high GGT, in contrast, was significantly associated with NR (p < 0.0001). A strong correlation was found between log(10) GGT and a scoring variable S (r = -0.26 for prediction of SVR, p < 0.001; r = 0.11 for prediction of NR, p = 0.016) summarizing predictive information from other baseline factors. CONCLUSIONS: These findings prove the predictive sensitivity of GGT as an independent indicator of nonresponsiveness even at levels that are slightly above the normal range. This new predictive parameter may help to improve individualized therapy in HCV type-1 infection.

wa3006

背景：基线因素的批判性分析被认为是有用的预测病毒学无应答（星期日），复发或持续病毒学应答（SVR）在接受抗病毒药物治疗的丙型肝炎病毒（HCV）感染的患者。在本回顾性研究中，我们试图找出是否可能是γ-谷氨酰转肽酶（GGT）的特殊预测能力的基本因素之一。我们分析，在不同的治疗结果与GGT的组合，或独立评估的GGT的预测值的预测能力，建立基线因素的患者。方法：慢性丙型肝炎病毒1型（N = 561）或2 / 3（N = 71）感染的632例患者的个人数据进行了分析。所有患者已收到他们的抗病毒治疗的第一期培训班，并与聚乙二醇干扰素α- 2a或- 2b干扰素加利巴韦林治疗。结果：在与丙型肝炎病毒类型1，一个多元多项式logistic回归分析，确定低氨酰转肽酶（P <0.0001），高胆固醇患者（P <0.0001），年龄≤40年（P <0.0001），谷丙转氨酶（P = 0.0006） ，低血症（P = 0.0014），并没有肝硬化的独立预测因素（P = 0.0164）。 ，虽然这些基线因素预示着改善病毒学应答，高GGT的，相反，显着关联（P <0.0001）与NR。很强的相关性被发现之间的日志（10）GGT和一个得分变量S（R = -0.26的SVR的预测，P <0.001; R = 0.11预测的NR，P = 0.016），总结从其他基线因素的预测信息。结论：这些研究结果证明，GGT的水平，略高于正常范围，即使在独立的nonresponsiveness指标的预测灵敏度。这个新的预测参数可能有助于提高在H​​CV - 1型感染的个体化治疗。(源于google翻译)