男性HBV更易癌变

冻顶乌龙

SUMMARY: Older patients and men with chronic hepatitis B virus (HBV) infection were more likely to progress to liver cancer, decompensated cirrhosis, and liver-related death, while Asian patients had lower progression rates, according to an analysis of Kaiser Permanent members presented at the recent American Association for the Study of Liver Diseases "Liver Meeting" (AASLD 2010) in Boston. Diabetes and heavy alcohol use also predicted poor outcomes.
   
   
By Liz Highleyman
Over years or decades, chronic hepatitis B can lead to serious liver disease, including cirrhosis, hepatocellular carcinoma (HCC, a form of liver cancer), and liver failure, or decompensation, that requires a transplant or leads to death.
M. Manos and colleagues looked at long-term outcomes among a diverse population of chronic hepatitis B patients in the Kaiser Permanente Medical Care Program, a comprehensive managed care and health insurance system.
This retrospective, longitudinal analysis included nearly 12,000 adult Kaiser Permanent patients with chronic hepatitis B seen for at least 2 consecutive years during 1999-2007. With regards to co-existing conditions, 6% were ever diabetic and 3% had ever had an alcohol abuse diagnosis; individuals with HIV or hepatitis C coinfection were excluded.
Out of a total of 11,932 eligible patients, 10,584 had recorded information about their race/ethnicity. Half were men and the average age at study entry was 43 years. More than 80% were Asian/Pacific Islanders, reflecting that HBV is endemic in many Asian countries and is often transmitted perinatally from mother to child. Most participants (89%) had never been treated for hepatitis B.
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摘要：老年患者和男性慢性乙型肝炎病毒（乙型肝炎病毒）感染更有可能取得的进展肝癌，肝硬化失代偿和肝脏有关的死亡，同时，亚洲患者有较低的进展率，据分析皇帝常任理事国在最近的美国肝脏疾病研究协会的“肝”（2010）在波士顿的美国肝病学会年会。糖尿病和酒精的使用也预测穷人的成果。

丽兹highleyman

过去几年或几十年，慢性乙型肝炎可导致严重的肝脏疾病，如肝硬化，肝癌（肝癌，肝癌的一种形式），与肝功能衰竭，或失代偿，需要移植或导致死亡的。

·马诺斯和同事在长期成果的不同人口之间的慢性乙型肝炎患者在凯泽永久医疗计划，全面的护理和医疗保险制度。

这种回顾性，纵向分析包括近12000成人凯泽永久性慢性乙型肝炎患者看到至少连续2年在1999-2007。至于共存的条件，6%是糖尿病和3%曾有酗酒诊断；个人与艾滋病毒或丙型肝炎感染被排除。

总共有11932的患者有资格，10584有记录的信息对他们的种族/族裔。一半是男性，平均年龄在研究项目为43年。超过80%的亚洲/太平洋岛民，反映乙肝病毒流行在许多亚洲国家，往往是围产期母婴传播。大多数与会者（89%）从来没有治疗乙肝。

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