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咖啡对肝好,有助于减少纤维化。
Liver protectionCoffee can also reduce the incidence of cirrhosis of the liver[16] and has been linked to a reduced risk of hepatocellular carcinoma, a primary liver cancer that usually arises in patients with preexisting cirrhosis.[17] The exact mechanism and the amount of coffee needed to achieve a beneficial effect have long been unclear.[18] The cytokine transforming growth factor (TGF) beta has long been recognized for promoting fibrosis ability acting through the Smad family of transcription factors. In an interesting report recently published in the Journal of Hepatology, Gressner and colleagues provide the first mechanistic context for the epidemiological studies on coffee drinkers by showing that caffeine may have potent anti-fibrotic capabilities through its ability to antagonize the Smad pathway.[19]
[http://en.wikipedia.org/wiki/Health_effects_of_coffee#Liver_protection]
保护肝脏
咖啡也可以降低肝硬化的发生率[16],并已与降低风险的肝癌,原发性肝癌,通常在预先存在的肝硬化患者出现[17]的确切机制和咖啡的数量。需要实现一个有利的影响一直不清楚。[18]的细胞因子,转化生长因子(TGF)β早已通过的Smad家族的转录因子促进纤维化的能力的认可。 [19]在肝脏病杂志最近发表了一个有趣的报告,Gressner和他的同事提供第一机械上下文喝咖啡的流行病学研究显示,咖啡因可能通过其能力拮抗Smad通路的强有力的抗肝纤维化功能。 |