- 现金
- 300 元
- 精华
- 0
- 帖子
- 126
- 注册时间
- 2011-4-7
- 最后登录
- 2012-7-11
|
Bleeding In Cirrhosis Patients May Be Reduced By Adherence To Practice Guidelines
依照临床指南可能降低肝硬化患者出血风险
Compliance with practice guideline-recommended treatment for cirrhosis is associated with a reduction in first esophageal variceal hemorrhage (EVH; bleeding), according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute. Cirrhosis is a condition in which the liver is permanently scarred or injured.
根据一项发表在临床胃肠和肝病学杂志上的最新研究:对肝硬化患者依照临床指南推荐的治疗可降低食管曲张静脉出血(EVH)风险。该杂志是美国胃肠病协会官方杂志。肝硬化是指肝脏不可逆受损和瘢痕形成。
"Esophageal variceal hemorrhage is a serious complication of cirrhosis, and the mortality rate associated with it is high at 20 percent," said Jayavani Moodley, MD, of the Cleveland Clinic Foundation and lead author of the study. "This high mortality rate makes primary prevention of bleeding the best approach to improving outcomes for these patients."
美国俄亥俄州克利夫兰医学基金会的Jayavani Moodley 博士,同时也是本研究的首席作者指出:“EVH是肝硬化的严重并发症,死亡率高达20%。如此高的死亡率使得,对这类病人,将预防出血作为首要任务是改善预后的最好方式。”
In this study, doctors conducted an Institutional Review Board-approved retrospective chart review on 179 adult patients selected by computerized randomization, newly evaluated for cirrhosis at the Cleveland Clinic from 2003 to 2006. These patients were followed for 23 months; doctors assessed actual compliance rates of gastroenterologists with current practice guidelines, which recommend screening and intervention for high-risk esophageal varices. Subsequent bleeding rates were also determined.
在此项研究中,医生按惯例进行了一项董事会支持的回顾性研究,纳入179例电脑随机选取的成人患者,均为2003至2006年在克利夫兰医院新确诊的肝硬化患者。这些患者均随访23个月。医生评估了胃肠病专家实际按照临床指南的遵从率,该指南亦包含对有食管静脉曲张高风险的内镜筛查和治疗,同时给出了精确的出血几率。
The study authors reported that 94 percent of the patients had a screening endoscopy (EGD), with 80 percent having one within six months of the initial visit. Varices were present in half of the patients. In addition, 68 percent of all patients screened and 91 percent with large varices received a practice guideline-recommended treatment.
在作者的研究中,179例患者中有94%在第一次确诊时做了胃镜,有80%在六个月后的第一次随访中做了第二次胃镜。一半病人有静脉曲张。另外,在行胃镜检查的病人中有68%做了临床指南推荐的治疗,而对于严重的静脉曲张患者,行治疗的比例为91%。
Seven percent had an episode of EVH; 82 percent of patients without bleeding had their screening EGD within six months versus 50 percent of those with bleeding. The likelihood of bleeding at two years, as predicted by the North Italian Endoscopy Club model, was 13 percent versus 27 percent.
7%的患者发生了食管曲张静脉出血;未出血的患者中有82%在六个月内接受过胃镜检查,而在出血患者中同期做过胃镜的比例只有50%。根据北意大利内镜俱乐部的模型预测,2年内两组病人发生出血的可能性前者为13%,而后者为27%。
"Our study suggests that the significant reduction in observed bleeding rates may be related to adherence to practice guideline-recommended care. Patients who did not bleed were more likely to have received their screening EGD within the six-month window as compared to those who bled, demonstrating the effectiveness of early variceal screening," added Dr. Moodley.
Moodley补充说:”我们的研究提示:观察到的出血率的显著下降可能与遵从了临床指南推荐的治疗有关。未出血组病人与出血组相比,在六个月内的出血高发期更多的接受了内镜检查,显示了静脉曲张筛查的有效性。”
The risk of developing gastroesophageal varices in patients with cirrhosis is between 50 percent and 66 percent, and 30 percent to 40 percent of patients with varices suffer a variceal hemorrhage. If untreated, variceal hemorrhage portends a 70 percent risk of death within one year.
肝硬化病人有50-66%会发生食管胃底静脉曲张,有静脉曲张的病人中有30-40%会发生曲张静脉出血。如果不治疗,曲张静脉出血预示70%会在一年内死亡。
About Cirrhosis:
Cirrhosis occurs when the liver is permanently scarred or injured by chronic conditions and diseases. The scar tissue that forms in cirrhosis harms the structure of the liver, blocking the flow of blood through the organ.
关于肝硬化:
由慢性肝病导致的不可逆肝脏损伤和瘢痕形成即为肝硬化。肝硬化中形成的瘢痕组织破坏肝脏结构,阻断了流经肝脏的血流。
Source:
Alissa J. Cruz
American Gastroenterological Association
来源
Alissa J. Cruz
美国胃肠病协会
编译:
依照临床指南可能降低肝硬化患者出血风险
根据一项发表在临床胃肠和肝病学杂志上的最新研究:对肝硬化患者依照临床指南推荐的治疗可降低食管曲张静脉出血(EVH)风险。该杂志是美国胃肠病协会官方杂志。肝硬化是指肝脏不可逆受损和瘢痕形成。
美国俄亥俄州克利夫兰医学基金会的Jayavani Moodley 博士,同时也是本研究的首席作者指出:“EVH是肝硬化的严重并发症,死亡率高达20%。如此高的死亡率使得,对这类病人,将预防出血作为首要任务是改善预后的最好方式。”
在此项研究中,医生按惯例进行了一项董事会支持的回顾性研究,纳入179例电脑随机选取的成人患者,均为2003至2006年在克利夫兰医院新确诊的肝硬化患者。这些患者均随访23个月。医生评估了胃肠病专家实际按照临床指南的遵从率,该指南亦包含对有食管静脉曲张高风险的内镜筛查和治疗,同时给出了精确的出血几率。
在作者的研究中,179例患者中有94%在第一次确诊时做了胃镜,有80%在六个月后的第一次随访中做了第二次胃镜。一半病人有静脉曲张。另外,在行胃镜检查的病人中有68%做了临床指南推荐的治疗,而对于严重的静脉曲张患者,行治疗的比例为91%。
7%的患者发生了食管曲张静脉出血;未出血的患者中有82%在六个月内接受过胃镜检查,而在出血患者中同期做过胃镜的比例只有50%。根据北意大利内镜俱乐部的模型预测,2年内两组病人发生出血的可能性前者为13%,而后者为27%。
Moodley补充说:”我们的研究提示:观察到的出血率的显著下降可能与遵从了临床指南推荐的治疗有关。未出血组病人与出血组相比,在六个月内的出血高发期更多的接受了内镜检查,显示了静脉曲张筛查的有效性。”
肝硬化病人有50-66%会发生食管胃底静脉曲张,有静脉曲张的病人中有30-40%会发生曲张静脉出血。如果不治疗,曲张静脉出血预示70%会在一年内死亡。
关于肝硬化:
由慢性肝病导致的不可逆肝脏损伤和瘢痕形成即为肝硬化。肝硬化中形成的瘢痕组织破坏肝脏结构,阻断了流经肝脏的血流。
来源
Alissa J. Cruz
美国胃肠病协会 |
|