Annual Rate and Predictors of HBeAg, HBV DNA and HBsAg Seroclearance

StephenW

This is an extract from the following paper. The complete paper is available at:
http://www.medscape.com/viewarticle/741368

                                                                                             
From Journal of Gastroenterology and Hepatology
Natural History of Chronic Hepatitis B REVEALed

Chien-Jen Chen; Hwai-I Yang

Authors and Disclosures

Posted: 05/12/2011; J Gastroenterol Hepatol. 2011;26(4):628-638. © 2011 Blackwell Publishing

Annual Rate and Predictors of HBeAg, HBV DNA and HBsAg Seroclearance  

Seroclearance of HBeAg, HBV DNA, and HBsAg are important clinical outcomes for chronic hepatitis B treatment trials. Few studies have explored the incidence and determinants of spontaneous seroclearance using a long-term follow-up study. The annual seroclearance rates of HBeAg, HBV DNA and HBsAg have been estimated, respectively, for 439 HBeAg-seropositive participants with serum HBV DNA level ≥ 10 000 copies/mL, 1289 participants with serum HBV DNA level ≥ 10 000 copies/mL at enrollment, and 3087 HBsAg-seropositives in REVEAL-HBV study.[27–30] The annual seroclearance rate was 5.92% for HBeAg, 1.97% for HBV DNA, and 2.26% for HBsAg. The annual HBeAg seroclearance rate for HBeAg-seropositive participants who had serum HBV DNA levels ≥ 100 000 000 copies/mL was 4.44%.[28,29] The annual HBV DNA seroclearance rate after the seroclearance of HBeAg was 3.20%.[27] The annual HBsAg seroclearance rate after the seroclearance of HBV DNA was around 6%. In other words, the cumulative incidence of HBsAg seroclearance at 60 and 100 months after serum HBV-DNA level decreased to undetectable was 25.8% and 51.3%, respectively.[30]     
                  
Significantly higher HBeAg seroclearance rates were observed for female gender, elevated serum ALT level at entry (≥ 45 vs < 45 IU), low serum HBV DNA level (< 100 000 vs≥ 100 000 copies/mL), HBV genotype B/B + C (vs genotype C), and HBV precore G1896A mutant (vs wild type). The predictors of seroclearance of HBV DNA included low serum HBV DNA level (< 100 000 copies/mL) and central obesity (waist circumference > 90 cm in men and > 80 cm in women). The HBsAg seroclearance was significantly associated with increasing age, low serum HBV DNA level (< 100 000 vs≥ 100 000 copies/mL), high body mass index (≥ 30 vs < 30 kg/m2) and ethnicity of mainland Chinese (vs ethnicity of Hakka and Fukkienese

侬是马甲

连接好像有问题？

大哥是陆军

翻译下

StephenW

侬是马甲 发表于 2011-8-20 18:35
连接好像有问题？

我测试了，没有问题.

侬是马甲

StephenW 发表于 2011-8-20 19:13
我测试了，没有问题.

需要注册

StephenW

回复 大哥是陆军 的帖子

胃肠病学和肝病学杂志
慢性乙型肝炎的自然史发现

陈建仁;杨怀我

作者及披露

发表于：2011年5月12日;胃肠肝胆病。 2011，26（4）:628 - 638。 © 2011布莱克韦尔出版
按年率计算和预测对HBeAg，HBV DNA和乙肝表面抗原血清消除

对HBeAg，HBV - DNA和HBsAg 血清消除 慢性乙型肝炎的治疗试验的重要临床结局。很少有研究探讨自发seroclearance的发病率和使用一个长期的随访研究的决定因素。已估计，每年对HBeAg，HBV - DNA和HBsAg 血清消除率分别为439例HBeAg血清学阳性血清HBV DNA水平的参与者，≥10 000拷贝/毫升，1289参与者与血清HBV DNA水平≥10万拷贝/ ml，在入学和3087例HBsAg seropositives REVEAL - HBV的研究[27-30] 血清消除率每年5.92％e抗原，HBV - DNA为1.97％，和2.26％，乙肝表面抗原。 [27]每年e抗原HBeAg血清阳性的参与者曾血清HBV DNA水平≥100 000 000拷贝/ ml 血清消除率是4.44％[28,29]每年的乙肝病毒DNA后HBeAg的血清消除血清消除率是3.20％。每年的乙肝表面抗原后的HBV DNA 血清消除 seroclearance率约为6％。换句话说，乙肝表面抗原血清消除在60至100个月后血清HBV - DNA水平降低到检测不到的累积发病率是25.8％和51.3％，分别为[30]。
                  
HBeAg的血清消除率明显高于女性，高架入口血清ALT水平（≥45 VS <45 IU），低血清HBV DNA水平（<100 000 VS≥100 000拷贝/毫升），观察HBV基因型B / B + C（与C型），和HBV前C区G1896A突变（与野生型）。 HBV - DNA 血清消除的预测低血清HBV DNA水平（<100 000拷贝/ mL）和中央肥胖（腰围> 90厘米的男性和女性80厘米）。乙肝表面抗原血清消除显着相关，与年龄的增加，低血清HBV DNA水平（<100 000 VS≥100 000拷贝/毫升），高体重指数（≥30与<30 kg/m2）和中国大陆的种族（种族VS客家和Fukkienese)

大哥是陆军

在线翻译的理解不了

alex1234

high body mass index (≥ 30 vs < 30 kg/m2) ->那是超胖的人，一般有脂肪肝了

StephenW

alex1234 发表于 2011-8-21 20:21
high body mass index (≥ 30 vs < 30 kg/m2) ->那是超胖的人，一般有脂肪肝了

I must agree this is strange, we need to read the full paper. Fatty liver may be associated with liver damage, but does it reduce chances of seroclearance of HbsAg?

把握当下

e血清转换跟免疫、dna、基因型、是否变异有关：
alt高的比低的容易转(≥ 45 vs < 45 IU), dna低的比高的容易转
(< 100 000 vs≥ 100 000 copies/mL)，B/B + C基因型比c基因型容易转，前c区G1896A变异比野毒株容易转。

首先dna不转其他都是浮云
其次e要是比dna先转了更令人纠结：变异后抗病毒就像在黑暗的隧道里摸索前进，没有e定量照耀前路