Lancet Onco.：乙肝病毒感染者患非霍奇金淋巴瘤风险高

tonychant

美韩研究人员在英国《柳叶刀·肿瘤学》（Lancet Oncogene）杂志上报道称，乙肝病毒感染者患非霍奇金淋巴瘤的风险高于未感染者。

美国国家癌症研究所和韩国延世大学研究人员分析了参与韩国癌症预防研究的60多万人的病例数据，其中约5．3万人乙肝病毒检测呈阳性。在1995年进行大规模乙肝疫苗接种前，韩国是世界卫生组织确定的乙肝大国，高峰时有超过7％的韩国人感染了乙肝病毒。

研究人员发现，感染乙肝病毒者14年后患非霍奇金淋巴瘤的比例约为十万分之十九点四；而未感染乙肝病毒者患非霍奇金淋巴瘤的比例约为十万分之十二点三。

研究人员表示，这项研究表明，乙肝病毒感染者患非霍奇金淋巴瘤的风险较高，但还需要进一步研究确认二者的关联是否为偶然现象。

淋巴瘤是起源于淋巴结或其他淋巴组织的恶性肿瘤，主要分为霍奇金淋巴瘤和非霍奇金淋巴瘤。原文出处：

The Lancet Oncology doi:10.1016/S1470-2045(10)70167-4

Hepatitis B virus infection and risk of non-Hodgkin lymphoma in South Korea: a cohort study
Eric A Engels MD a, Eo Rin Cho PhD b, Prof Sun Ha Jee PhD c

Hepatitis B virus (HBV) infection is common throughout Asia and Africa. Whether chronic HBV infection increases risk of non-Hodgkin lymphoma (NHL) is unclear. We aimed to assess the association between chronic HBV infection and subsequent development of NHL in a South Korean cohort.

The Korean Cancer Prevention Study is a cohort study of South Korean workers and their dependants enrolled during 1992—95. From this cohort, we excluded individuals who died before Jan 1, 1993, who had cancer at or before the initial visit, who had missing information about weight, height, alanine aminotransferase or aspartate aminotransferase concentrations, or alcohol use, or who had evidence of HIV or HCV infection. Of 1 284 586 eligible participants, 603 585 had baseline data for serum hepatitis B surface antigen (HBsAg) status and were included in our study. We regarded HBsAg positivity at baseline as evidence of chronic HBV infection. Participants were followed up from baseline until Dec 31, 2006. We used national databases of inpatient and outpatient diagnoses and mortality records to ascertain occurrence of haematological malignancies. We assessed incidence of NHL overall and of NHL subtypes, malignant immunoproliferation, Hodgkin's lymphoma, multiple myeloma, and various leukaemias. We used Cox regression to evaluate associations with HBsAg status, adjusting for sex, age, and enrolment year.

The Korean Cancer Prevention Study is a cohort study of South Korean workers and their dependants enrolled during 1992—95. From this cohort, we excluded individuals who died before Jan 1, 1993, who had cancer at or before the initial visit, who had missing information about weight, height, alanine aminotransferase or aspartate aminotransferase concentrations, or alcohol use, or who had evidence of HIV or HCV infection. Of 1 284 586 eligible participants, 603 585 had baseline data for serum hepatitis B surface antigen (HBsAg) status and were included in our study. We regarded HBsAg positivity at baseline as evidence of chronic HBV infection. Participants were followed up from baseline until Dec 31, 2006. We used national databases of inpatient and outpatient diagnoses and mortality records to ascertain occurrence of haematological malignancies. We assessed incidence of NHL overall and of NHL subtypes, malignant immunoproliferation, Hodgkin's lymphoma, multiple myeloma, and various leukaemias. We used Cox regression to evaluate associations with HBsAg status, adjusting for sex, age, and enrolment year.

During extended follow-up, HBsAg-positive individuals had an increased risk of NHL, suggesting that chronic HBV infection promotes lymphomagenesis.