[英语新闻] 需要提防新的致癌物质 -Riddelliine[有关 猪屎豆]

StephenW

http://the-scientist.com/2011/06/13/new-carcinogens-to-watch-out-for/
Riddelliine: Found in some plants of the daisy family, common in the western United States, this compound is now listed as a “reasonably anticipated” carcinogen as a result of rodent studies that show it can cause leukemia, liver cancer, lung tumors, and cancer of the blood vessels. While no riddelliine-containing plants are used for food or commercial purposes in the United States, at least 13 species are used in herbal medicines, and may be consumed as food in other parts of the world. Exposure could also result from consuming animal products from species that feed on the plants.
Riddelliine：发现在菊家庭，在美国西部常见的一些植物，这种化合物是目前被列为“合理预期“作为，显示它可能会导致白血病，肝癌，肺癌肿瘤的老鼠的研究结果致癌物质，癌症的血管。虽然没有riddelliine含植物是食品或美国商业用途，至少有13种中药材中使用，并可能在世界其他地区粮食消耗。曝光也可能导致因食用动物产品从种上植物饲料。

Riddelliine belongs to a class of toxic pyrrolizidine alkaloids and is isolated from plants of the genera Crotalaria, Amsinckia, and Senecio that grow in the western United States.
Riddelliine属于一种有毒的生物碱类，吡咯是从猪屎豆属，Amsinckia和千里光，在美国西部植物生长孤立。
《全国中草药汇编》:猪屎豆

【别名】野花生、猪屎青、土沙苑子、大马铃

【来源】豆科猪屎豆属植物猪屎豆Crotalaria mucronata Desv.，以根、茎、叶及种子入药。夏秋采，晒干。

【毒性】猪屎豆种子及叶含大量生物碱，可通过皮肤吸收，主要对肝脏表现毒性，但不出贫血、血清总蛋白降低、血浆凝血酶原时间（大鼠）延长。开花期植物的叶喂饲山羊可引起中毒，干枯物则失去毒性。雷卓碱对大鼠腹腔注射的半数致死量为37mg/kg。