[英语新闻]定量分析方法来识别乙肝标志物

StephenW

http://www.chromatographytoday.com/news/electrophoretic-separations/35/breaking_news/quantitative_analysis_used_to_identify_hepatitis_b_biomarker/15584/

Electrophoretic Separations
Quantitative analysis used to identify hepatitis B biomarker
Thursday 9 June 2011                                                
        

The systematic identification of specific proteins which are key factors in disease progression through quantitative analysis is essential to understanding illnesses.

In a study published by the Virology Journal, a team of scientists aimed to identify the proteins specific to hepatitis B virus (HBV) induced hepatitis.

The team claimed that although many proteins have been found that are known to have an impact on hepatitis, the fact that no systematic protein screening has been documented is hindering the understanding and treatment of the disease.

As a result of the study they found, through two-dimensional electrophoresis (2-DE), peptide mass fingerprinting (PMF) analysis, that the expression level of alpha-1 antitrypsin (AAT) was significantly elevated in serum samples from patients with severe chronic hepatitis.

Furthermore, the scientists discovered that AAT is with highest expression in normal tissue and cells, and lowest in hepatic carcinoma and severe chronic hepatitis tissues and cells, suggesting the specific secretion of AAT from tissues and cells to serum.

The team concluded that AAT, therefore, has the potential to act as a biomarker for hepatitis B in diagnosis, aiding treatment.

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StephenW

该疾病是通过定量分析的具体进展的关键因素是至关重要的蛋白质鉴定系统了解疾病。

由病毒学杂志，一个旨在确定特定的蛋白质乙型肝炎病毒（HBV）引起的肝炎科学家发表的一项研究。

该小组称，虽然许多蛋白质已被发现，已知有一对肝炎，没有系统的蛋白筛检已经记录是阻碍的理解和治疗该疾病影响的事实。

作为这项研究的结果，他们发现，通过双向电泳（2 - DE）的，肽质量指纹图谱（PMF的）的分析，认为α-1抗胰蛋白酶（AAT）的表达水平显着患者血清中重度升高慢性肝炎。

此外，AAT的科学家发现，与正常组织和最高的细胞中的表达，并在肝癌和严重慢性肝炎组织和细胞最低，这表明AAT的组织和细胞的血清特异性分泌。

研究小组得出结论认为AAT
，因此，有可能作为诊断乙肝标志物，协助处理。