[英语研究]瞬时弹性(transient elastography)评估慢性乙肝纤

StephenW

<http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04722.x/abstract>

Dual cut-off transient elastography to assess liver fibrosis in chronic
hepatitis B: a cohort study with internal validation

M. Viganò1,2, S. Paggi3, P. Lampertico1, M. Fraquelli3, S. Massironi3, G.
Ronchi1, C. Rigamonti1, D. Conte3, M. Colombo1

Article first published online: 1 JUN 2011
DOI: 10.1111/j.1365-2036.2011.04722.x
© 2011 Blackwell Publishing Ltd
Issue

Alimentary Pharmacology & Therapeutics
Early View (Online Version of Record published before inclusion in an
issue)

Summary

Background  Transient elastography has gained popularity to stage liver
fibrosis in chronic viral hepatitis, however, diagnostic cut-offs for
severe fibrosis in chronic hepatitis B are poorly defined.

Aim  To evaluate an algorithm with two distinct cut-offs for positive and
negative prediction of significant fibrosis and cirrhosis in chronic
hepatitis B patients.

Methods  Two cohorts of treatment-naïve patients with chronic hepatitis B
(125 training and 92 validations) were consecutively and concurrently
examined by percutaneous liver biopsy and transient elastography. Fibrosis
was staged by Metavir (significant fibrosis = F ≥ 2; cirrhosis = F4) in
≥2 cm long liver tissue cores.

Results  A >13.1 kPa positive and a ≤9.4 kPa negative cut-off for
cirrhosis had a >90% sensitivity and specificity, with an accuracy of 94%.
The corresponding cut-offs for F ≥ 2 were >9.4 and ≤6.2 kPa, thus
classifying 56% of patients with an overall accuracy of 90%. In the
validation cohort, F4 and F ≥ 2 were predicted by the above transient
elastography cut-offs with an overall accuracy >90%. In 165 patients with
higher than upper limit of normal transaminase activity the dual cut-off
algorithm of transient elastography was as accurate as in the 52 patients
with normal alanine aminotransferase values in the prediction and exclusion
of cirrhosis, only.

Conclusions  A dual cut-off algorithm allowed for correctly classifying
both significant fibrosis and cirrhosis in the majority of the patients
with chronic hepatitis B, independent of alanine aminotransferase values,
thus reducing the need for liver biopsy investigations.



(6.合.彩).足球.篮球...各类投注开户下注

第一投注.现金网:招代理年薪10万以上:6668.cc

StephenW

双截止瞬时弹性，以评估慢性肝纤维化
乙肝：一个内部验证队列研究

1,2米Viganò，学Paggi 3，第Lampertico 1米Fraquelli 3，学Massironi三湾
Ronchi1，角里加蒙蒂一，四康特3米科伦坡1

文章首先发表时间：2011年6月1日
分类号：10.1111/j.1365-2036.2011.04722.x
© 2011布莱克韦尔出版有限公司
发行

消化系统药理学与治疗学
早期查看（网络版日前发表记录列入一
问题）

综述

背景瞬时弹性得到了普及阶段肝脏
慢性病毒性肝炎肝纤维化，然而，诊断供应被切断的
慢性乙型肝炎是严重纤维化定义不清。

目的评价两种不同的算法与切割积极和取舍
阴性预测重大慢性纤维化和肝硬化
乙型肝炎患者。

两种方法治疗初治患者的队列与慢性乙型肝炎
（125验证培训和92）的连续兼
经皮肝穿刺检查和短暂的弹性。纤维化
为举办的Metavir（= F的显着肝纤维化≥2;肝硬化= F4键）在
≥2厘米长的肝组织核心。

结果A> 13.1千帕的积极和消极≤9.4千帕截止
肝硬化有“90％的敏感性和特异性，用94％的准确率。
相应截止起飞的F≥2人> 9.4和≤6.2千帕，从而
分类与90％的整体准确度56％的患者。在
验证队列，F4键和F≥2例以上所预测的瞬间
弹性切割，进行全面准确权衡“90％。在165例
转氨酶高于正常上限的双重活动截止
瞬时弹性成像算法一样准确，在​​52个病人
与正常的预测和排斥谷丙转氨酶值
肝硬化，只。

结论甲双截止允许正确分类算法
同时显着纤维化和肝硬化的患者中多数
慢性乙型肝炎，丙氨酸氨基转移酶值无关，
从而减少了对肝活检调查的需要。

红军哥

StephenW 发表于 2011-6-8 14:47
双截止瞬时弹性，以评估慢性肝纤维化
乙肝：一个内部验证队列研究

你翻译得很难看得懂，应该是用google翻译软件翻的吧？

StephenW

回复 红军哥 的帖子


是的。谷歌不是100％准确，只是一个粗略的指南.

红军哥

这个文献是从那里出搞出来的啊，期刊么？

红军哥

哦，看到出处了

红军哥

哦，看到出处了

StephenW

回复 红军哥 的帖子

             Issue           

Alimentary Pharmacology &Therapeutics
DOI: 10.1111/j.1365-2036.2011.04722.x
Dual cut-off transient elastography to assess liver fibrosis in chronic hepatitis B: a cohort study with internal validation

• M. Viganò1,2,
• S. Paggi3,
• P. Lampertico1,
• M. Fraquelli3,
• S. Massironi3,
• G. Ronchi1,
• C. Rigamonti1,
• D. Conte3,
• M. Colombo1
  

Article first published online: 1 JUN 2011