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喝咖啡提高丙型肝炎治疗的反应 [复制链接]

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发表于 2011-6-7 23:05 |只看该作者 |倒序浏览 |打印
Contact: Alissa J. Cruz
[email protected]
301-272-1603
American Gastroenterological Association
Coffee drinking improves hepatitis C treatment response         Advanced hepatitis C patients with chronic liver disease may benefit from drinking coffee during treatment, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Patients who received peginterferon plus ribavirin treatment and who drank three or more cups of coffee per day were two times more likely to respond to treatment than non-drinkers.
        "Coffee intake has been associated with a lower level of liver enzymes, reduced progression of chronic liver disease and reduced incidence of liver cancer," said Neal Freedman, PhD, MPH, of the National Cancer Institute and lead author of this study. "Although we observed an independent association between coffee intake and virologic response to treatment, this association needs replication in other studies."
        Among non-drinkers, 46 percent had an early virologic response; 26 percent had no detectable serum hepatitis C virus (HCV) ribonucleic acid at week 20; 22 percent had no detectable serum at week 48; and 11 percent had a sustained virologic response. In contrast, the corresponding proportions for those who drank three or more cups of coffee per day were 73 percent, 52 percent, 49 percent and 26 percent, respectively.
        Approximately 70 to 80 percent of individuals exposed to HCV become chronically infected. Worldwide, these individuals are estimated to number between 130 and 170 million. Higher coffee consumption has been associated with slower progression of pre-existing liver disease and lower risk of liver cancer. However, the relationship with response to anti-HCV treatment had not been previously evaluated. Treatment with peginterferon and ribavirin resolves chronic hepatitis C in about half of patients. It is unknown whether coffee will improve response with the addition of new drugs that were recently approved for use in the U.S.
        Because patients in the Hepatitis C Antiviral Long-term Treatment against Cirrhosis Trial also had previously failed interferon therapy, it is not clear whether the results can be generalized to other patient populations. Future studies among patients with less advanced disease, those who are treatment-naïve to prior therapy, or who are being treated with newer antiviral agents are needed.
       

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        For more information on hepatitis, please read the AGA brochure "Understanding Hepatitis" at www.gastro.org/patient-center/digestive-conditions/hepatitis or visit the National Institute of Diabetes and Digestive and Kidney Diseases at http://digestive.niddk.nih.gov/ddiseases/pubs/hepc_ez.
        About the AGA Institute
The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include 17,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology. The AGA Institute administers the practice, research and educational programs of the organization. www.gastro.org.
        About Gastroenterology
Gastroenterology, the official journal of the AGA Institute, is the most prominent scientific journal in the specialty and is in the top 1 percent of indexed medical journals internationally. The journal publishes clinical and basic science studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The journal is abstracted and indexed in Biological Abstracts, Current Awareness in Biological Sciences, Chemical Abstracts, Current Contents, Excerpta Medica, Index Medicus, Nutrition Abstracts and Science Citation Index. For more information, visit www.gastrojournal.org.

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发表于 2011-6-7 23:05 |只看该作者
先进的C型肝炎与慢性肝病患者可能受益于治疗期间喝咖啡,根据一项在消化科的美国胃肠病协会(AGA)的新研究学会的官方杂志。患者接受聚乙二醇干扰素联合利巴韦林谁治疗,谁喝了三个或更多杯咖啡,每天有两次较有反应比不饮酒者的待遇。

“咖啡的摄入量已与肝酶的水平较低,降低慢性肝病和肝癌的发生率降低的进展,”尼尔o弗里德曼说,博士,公共卫生硕士,美国国家癌症研究所和本研究的主要作者。 “虽然我们观察到咖啡摄入量之间的病毒对治疗的反应和独立的协会,该协会在其他研究中需要复制。”

在非饮酒者,有百分之46的早期病毒学反应;有百分之26没有检测到20周时血清丙型肝炎病毒(HCV)的核糖核酸,22周时有百分之48没有检测到血清;和11个百分点有一个持续病毒学应答。相反,对于那些谁喝了三个或更多杯咖啡,每天相应比例分别为百分之73,百分之52,百分之49和百分之26,分别。

大约70到80个人暴露于HCV的百分之成为慢性感染。在世界范围内,这些人估计人数在130和170万美元。高等教育饮用咖啡与进展较​​慢的预先存在的肝脏疾病和肝癌的风险降低。然而,与应对反HCV治疗的关系已经没有以前的评估。聚乙二醇干扰素和利巴韦林治疗解决了约一半的患者慢性丙型肝炎。目前还不清楚咖啡将改善与新药物的补充,这是最近在美国批准使用的反应

因为在C型肝炎病毒长期治疗对肝硬化患者也有试用干扰素治疗以前没有,现在还不清楚结果是否可以推广到其他的病患族群。未来研究的患者较少先进的疾病,这​​些谁是治疗初治对之前的治疗,或者谁正在新的抗病毒药物治疗是必要的。

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发表于 2011-6-8 08:27 |只看该作者
  看样子要喝喝咖啡了,可是用咖啡后失眠不好解决啊

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发表于 2011-6-8 13:25 |只看该作者
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早上和下午可以。咖啡国外非常流行。
试试吧。

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发表于 2011-6-9 10:28 |只看该作者
我也试试吧
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发表于 2011-6-11 06:23 |只看该作者
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