[肝胆速递] 新生儿乙肝免疫项目25年后清除儿童肝癌和急性

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新生儿乙肝免疫项目25年后清除儿童肝癌和急性
Elimination of hepatocellular carcinoma and acute hepatitis B in children 25 years after a hepatitis B newborn and catch-up immunization program

[肝胆速递]：美国阿拉斯加在1984年之后实行新生儿乙肝免疫项目，在清除肝癌和急性乙肝取得很好效果。

http://onlinelibrary.wiley.com/doi/10.1002/hep.24442/abstract;jsessionid=25735B4EDEF3105FA96EB4FAC111626E.d03t02

AbstractAlaska Native people experienced the highest rates of acute and chronic hepatitis B virus (HBV) infection, and hepatocellular carcinoma (HCC) in the United States. We examine the effect of a universal newborn immunization with hepatitis B vaccine and mass population screening immunization program initiated in 1984 on rates of HBV and HCC in children 25 years later. During this time period, the population of Alaska Native people grew from an estimated 75,000 to 130,000 persons. A surveillance system to detect acute HBV infection in Alaska Native facilities was established in 1981. Cases of HCC in children under 20 years of age were identified using a National Cancer Institute (NCI) funded Cancer Registry established in 1969 coupled with an active surveillance program of screening persons with chronic HBV semiannually for alpha-fetoprotein since 1982. The incidence of acute symptomatic HBV infection in persons < 20 years of age fell from cases 19/100,000 in 1981-1982 to 0/100,000 in 1993-94, respectively. No cases of acute HBV have occurred in children since 1992. The incidence of HCC in persons < 20 years decreased from 3/100,000 in 1984-1988 to zero in 1995-1999 and no cases have occurred since 1999. The number of identified HBsAg-positive children < 20 years in the Alaska Native Population declined from 657 in 1987 to two in 2008. Universal newborn vaccination coupled with mass screening and immunization of susceptible Alaska Native has eliminated HCC and acute symptomatic HBV infection among Alaska Native children and this approach is the best way to prevent HBV related disease in children. (HEPATOLOGY 2011.)