[英语，审查]Effectiveness of a Chinese hamster cell derived HBV vaccine

StephenW

Vaccine. 2011 Mar 29. [Epub ahead of print]

Effectiveness of a Chinese hamster ovary cell derived hepatitis B vaccine
in Chinese Rural Communities.

Zhang Y, Ma JC, Qi SX, Wang F, Zhao C, Bi SL.
Chinese Center for Disease Control and Prevention, Institute for Viral
Disease Control and Prevention, Beijing 100052, PR China.

Abstract
OBJECTIVE: To evaluate the effectiveness of a Chinese hamster ovary cell
derived hepatitis B vaccine in a country community in Hebei Province, PR
China. METHOD: A cross-sectional investigation was carried out in 4 of 7
randomly selected country communities in Zhengding County in 2005. All of
the children who were born between 1997 and 1999 were selected as study
objects. Their serum samples were taken to test for HBV markers, and HBsAg
prevalence was compared to that of the same age group before hepatitis B
vaccination in 1983. In addition, for HBsAg positive children, their
mothers were visited and tested for serum HBV markers, in order to
distinguish maternal HBV transmissions. RESULTS: Among the 2205 children of
the selected birth cohort, 1696 (76.9%) were visited. The prevalence of
HBsAg was 0.53%, and by comparing to that of before hepatitis B
vaccination, the effectiveness was 95.3%, similar to that of yeast derived
hepatitis B vaccines. Among 7 mothers of HBsAg positive children, 5 were
HBsAg positive, indicating maternal HBV transmissions; and although one
mother was HBsAg negative, her kid was not vaccinated, which indicates a
horizontal transmission. As for the other kid, he was adopted and the HBV
infection status of his birth mother was unknown. CONCLUSION: The
effectiveness of the CHO derived hepatitis B vaccine is comparable to yeast
derived ones, and after the hepatitis B vaccination maternal transmission
is the most important route of spreading HBV.

Copyright © 2011. Published by Elsevier Ltd.

PMID: 21457729 [PubMed - as supplied by publisher]

StephenW

疫苗的研制。 2011年3月29日。 [EPUB的提前打印]

决策理论的中国仓鼠卵巢细胞源性乙肝疫苗
在中国农村社区。

张勇，马金城，齐绍先，王楼，赵C，毕Sl的。
中国疾病预防控制中心和预防病毒研究所
疾病控制和预防，北京100052，中国公关。

摘要
目的：评价一个中国仓鼠卵巢细胞的有效性
乙肝疫苗在河北省农村社区公关
中国。方法：采用横断面调查是在47
随机选择2005年在正定县国家的社区。全
谁是在1997年至1999年出生的儿童被选定为研究
对象。他们的血清样本，以测试乙肝病毒标志物，和HBsAg
患病率前相比，同一年龄组乙肝的
接种于1983年。此外，乙肝表面抗原阳性的儿童，他们的
参观和母亲血清乙肝病毒标志物检测，以便
区分产妇乙肝传输。结果：在2205儿童
选定的出生世代，1696年（76.9％）被访问。的患病率
乙肝表面抗原为0.53％，而相对于B型肝炎的前
接种疫苗的有效性为95.3％，与酵母派生
乙肝疫苗。在7个孩子的母亲HBsAg阳性，5例
乙肝表面抗原阳性，表明乙肝病毒母婴传输;，虽然一
母亲HBsAg阴性，她的孩子是没有接种疫苗，这表明
水平传播。至于其他的孩子，他是通过，乙肝病毒
他的亲生母亲感染状况不明。结论：
的CHO细胞乙肝疫苗的有效性媲美酵母
派生的，并经母婴传播乙肝疫苗接种
乙肝病毒传播是最重要的途径。

版权所有©2011。由Elsevier出版有限公司

结论：21457729[PubMed的- 由出版商提供]