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本帖最后由 风雨不动 于 2012-4-14 15:26 编辑
Method
Participants from GLOBE and another trial, Study 015, were offered a chance to receive open-label telbivudine for an additional 2 years in an open-label extension study (Study 2303). At EASL, the researchers presented pooled GLOBE/Study 015 efficacy and safety data for 503 patients (293 HBeAg positive and 210 HBeAg negative) who did not have genotypic resistance to telbivudine after 2 years and who continued taking the drug for 3 years. Most participants in the extension study were men and people of Asian race/ethnicity.
Results
HBV DNA suppression and ALT normalization were maintained in both HBeAg positive and HBeAg negative patients who took telbivudine for 3 years.
Among the 210 HBeAg negative participants, 85% achieved undetectable HBV DNA (< 300 copies/mL) and 84% experienced ALT normalization at year 3.
3年治疗结束,HBeAg阴性患者中,85%达到了HBV DNA低于300copies/mL的定量下限。84%ALT恢复正常。
Among the 293 HBeAg positive patients, 75% achieved undetectable HBV DNA and 83% experienced ALT normalization at year 3.
3年治疗结束后,HBeAg阳性患者中,75%达到了HBV DNA低于300copies/mL的定量下限。83%ALT恢复正常。
55% of these patients experienced HBeAg loss and 39% achieved HBeAg seroconversion.
55%的患者HBeAg消失,39%出现HBeAg血清学转换。
1.5% experienced hepatitis B surface antigen (HBsAg) loss and 0.4% (1 person) achieved HBsAg seroconversion.
HBeAg positive participants who had undetectable HBV DNA at week 24 of telbivudine therapy in the original GLOBE/Study 015 trials were more likely to achieve undetectable HBV DNA (87%), ALT normalization (86%), and HBeAg seroconversion (40%) at year 3.
Telbivudine continued to be generally well-tolerated at year 3, with a safety profile similar to that observed at year 2.
13% of patients experienced grade 3/4 creatine kinase (CK) elevation, 4% developed muscle pain, 0.6% experienced muscular weakness, and 0.3% developed myositis (muscle inflammation).
13% 3/4级CK升高,4%肌肉疼痛,0.6%肌肉无力,0.3%肌肉炎症。
The rate of peripheral neuropathy (including paresthesia, neuralgia, polyneuropathy, and sensory loss) was low, at < 1%
外周神经痛较低<1%
No cases of rhabdomyolysis, lactic acidosis, or other new serious safety concerns were observed with continued telbivudine use through year 3.
5.7% of HBeAg negative patients and 8.8% of HBeAg positive patients developed genotypic resistance to telbivudine at 3 years.
3年耐药 5.7% 8.8%
In a subset of 66 patients (all but 2 HBeAg positive) who discontinued telbivudine after achieving good response in the original GLOBE/Study 015 trials but continued follow-up during the extension study, 70% maintained low or undetectable HBV DNA, 64% maintained normal ALT, and 90% maintained HBeAg loss and HBeAg seroconversion.
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