核心和前C/核心启动子突变对未经治中老年人C基因型的肝癌

StephenW

<http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2893.2011.01458.x/abstract>

乙肝病毒的作用基地的核心和前C/核心启动子突变对
疗未经治的肝癌病人中老年人C基因型
Role of hepatitis B virus base core and precore/core promoter mutations on
hepatocellular carcinoma in untreated older genotype C Chinese patients

J-X. Zheng, Z. Zeng, Y. Y. Zheng, S-J. Yin, D-Y. Zhang, Y-Y. Yu, F. Wang

Article first published online: 4 APR 2011
DOI: 10.1111/j.1365-2893.2011.01458.x
© 2011 Blackwell Publishing Ltd
Issue

Journal of Viral Hepatitis
Early View (Online Version of Record published before inclusion in an
issue)

Summary.  The aim of the study was to investigate the prevalence of
mutations of basal core promoter (BCP) and precore (PreC) region of
hepatitis B virus (HBV) and their association with hepatocellular
carcinoma. A total of 341 untreated older HBV patients were divided into
three groups: chronic hepatitis B (CHB, 185), cirrhotic hepatocellular
carcinoma (LC-HCC, 113) and non-cirrhotic hepatocellular carcinoma
(non-LC-HCC, 43). HBV BCP and PreC mutations and genotypes were determined
by direct sequencing. Using univariate analysis, age (≥45 years), single
mutations including A1896 and A1899 and multiple mutations T1762/A1764 +
A1896, T1762/A1764 + A1899 and T1762/A1764 + A1896 + A1899 were more
frequently detected in LC-HCC and non-LC-HCC patients than in CHB patients.
BCP T1762/A1764 mutations were highly detected in LC-HCC patients than in
CHB patients. Multivariate logistic regression analysis (adjusted for age
and gender) revealed that among HBeAg-positive patients, BCP T1762/A1764
mutations (OR, 5.975; P = 0.05), PreC A1899 mutation (OR, 4.180; P = 0.013)
and multiple mutations T1762/A1764 + A1899 (OR, 6.408; P = 0.006) were
independently associated with the development of LC-HCC; PreC A1899
mutation (OR, 7.347; P = 0.034) was also independently associated with the
development of non-LC-HCC. On the other hand, among HBeAg-negative
patients, PreC A1896 mutation (OR, 5.176; P = 0.002) and multiple mutations
T1762/A1764 + A1896 (OR, 4.149; P = 0.007) were independently associated
with the development of non-LC-HCC. These results indicated that older age
(≥45 years) was associated with LC-HCC and non-LC-HCC development. BCP
T1762/A1764 mutations and PreC A1899 mutation were associated with the
LC-HCC development in HBeAg-positive patients. PreC A1896 mutation was
associated with the non-LC-HCC development in HBeAg-negative patients.

StephenW

乙肝病毒的作用基地的核心和前C /核心启动子突变对
未经治疗的肝癌病人中老年人C基因型

日本的X。郑，z的增华华郑的S -因子。阴，ð - Y的。张，Y型钇。郁，楼王

文章首先发表时间：2011年4月4日
分类号：10.1111/j.1365-2893.2011.01458.x
© 2011布莱克韦尔出版有限公司
发行

作者：病毒性肝炎
早期查看（网络版日前发表记录列入一
问题）

综述。这项研究的目的是调查患病率
的基本核心启动子（BCP）及前C区突变（前页）地区
乙型肝炎病毒（HBV）及其与肝癌的关联
癌。未经处理的341老乙肝患者共分为
三组：慢性乙型肝炎（CHB，185），肝硬化肝癌
癌（立法会，肝癌，113）和非肝硬化肝癌
（非信用证，肝癌，43）。乙型肝炎病毒BCP和前C基因突变进行了测定和基因型
通过直接测序。采用单因素分析，年龄（≥45岁），单
包括A1896变异和A1899和T1762/A1764多个突变基因突变+
A1896变异，T1762/A1764 + A1899及T1762/A1764 + + A1899 A1896变异较多
经常发现在LC - HCC和非的LC -肝癌比慢性乙型肝炎患者。
高度的BCP T1762/A1764突变检测的LC -肝癌患者比
慢性乙型肝炎患者。多因素Logistic回归分析（年龄调整
和性别）显示，在e抗原阳性的患者，口岸T1762/A1764
突变（OR为5.975，P值0.05），前C A1899突变（OR为4.180，P值0.013）
和T1762/A1764多个突变+ A1899（OR为6.408，P值0.006）为
独立相关的LC - HCC的发展;前C A1899
突变（OR为7.347，P值0.034）也独立地与有关
发展非的LC -肝癌。另一方面，在HBeAg阴性
患者，前C A1896变异突变（OR为5.176，P值0.002）和多基因突变
T1762/A1764 + A1896变异（OR为4.149，P值0.007）的独立相关
与非的LC -肝癌的发展。这些结果表明，年龄
（≥45岁）是与立法会，肝癌和非的LC -肝癌的发展。口岸
T1762/A1764突变和前C A1899变异与有关联
的LC -肝癌e抗原阳性患者的发展。前C A1896变异突变
在与e抗原阴性的患者非的LC -肝癌的发展。