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- 2002-7-10
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- 2002-7-16
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发表于 2002-7-11 00:07
I’m aPatient of chronic hepatitis B and looking forward to your help.
In 1988, I was found out I have be infected HBV, HbsAg(+), but ALT is
normal. In September 2000, I was found out HBsAg(+),HBeAg(+),HBcAb(+)
and ALT 187 IU/L. After observed 12 weeks without any drugs, the testing
results were HBsAg(+),HBeAg(+),HBcAb(+), ALT 198 IU/L,and HBV-DNA (PCR) positive (6.5*10E6 copies/ml), so given lamivudine 100mg gd on 29
November. 4 weeks later after taking lamivudine, HBV-DNA level became
undetectable and remained negative for 20 weeks,12 weeks later after
taking lamivudine, ALT(-),HBeAg(-) and HBeAb became slight positive,16
weeks later after taking lamivudine, ALT(-),HBeAg(-) and HBeAb became
positive and remained positive. On 15 June,2001 (taking lamivudine 24
weeks),I was admitted to stopped taking lamivudine. But after 4 weeks,
ALT 90U/L,HBeAg(-),HBeAb(+) and HBV-DNA positive (6*10E6 copy/ml), so
given lamivudine 100mg gd on 18 June again. 4 weeks later after taking
lamivudine again, HBV-DNA became negative and ALT decreased normal level and remain to 18 April 2002. The serum HBV-DNA testing at month 8 of
therapy again lamivudine that shows positive (1.21*10E5copies/ml). On 25 June), the testing of HBV-DNA increase to 7.17*10E7copies/ml) , ALT 344 IU/L, HBeAg(-) and HBeAb(-).ALT increase to 71 IU/L but HBV-DNA decrease to 3.21 *10E5 copies/ml on 26 May. I am in good condition until April 2002. Now I have some symptoms such as fatigue and anorexia.Since 27 June, I had been taking and Iv some drugs to decrease ALT and yesterday ALT was 98IU/L. My physician and I think I have emergence of YMDD
variant, but can’t know which kind variant (YIDD or YVDD). I was suggested to use INF- alpha 300mU QOD.Whether is INF- alpha good for me?Whether should I stop taking lamevudine? If I stop taking lamivudine, Which drug should I take? I wish you can give me some advice about
my disease.
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