Immunosuppressants Benefit Children With Liver Failure

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http://www.doctorslounge.com/index.php/news/pb/18001Immunosuppressants Benefit Children With Liver FailureLast Updated: February 21, 2011.

	Most children with autoimmune hepatitis treated with immunosuppressants recover liver function
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Most children with autoimmune hepatitis who have liver failurerespond well to immunosuppression therapy and can delay or avoid livertransplants, according to a study published in the February issue of Clinical Gastroenterology and Hepatology.MONDAY, Feb. 21 (HealthDay News) -- Most children withautoimmune hepatitis (AIH) who have liver failure respond well toimmunosuppression therapy and can delay or avoid liver transplants,according to a study published in the February issue of Clinical Gastroenterology and Hepatology.
Miriam L. Cuarterolo, M.D., from the Hospital de Pediatría Juan P.Garrahan in Buenos Aires, Argentina, and colleagues examined data from50 pediatric patients with AIH who had liver failure between 1996 and2008. Liver failure was defined as prothrombin time of less than 50percent. Patients were treated with 2 mg/kg prednisone per day at dosesof up to 60 mg per day, or 1 mg/kg prednisone per day up to 40 mg perday plus cyclosporine.
The investigators found that both approaches were similarlyeffective. Forty-five of the children (90 percent) achieved prothrombintime of greater than 50 percent in an average of 24 days. Of thesepatients, two required liver transplants because of portal hypertensioncomplications and three died from infection. Of the five nonresponders,three received transplants, one remained on the waiting list, and onedied from central nervous system bleeding.
"In our patients with cirrhosis secondary to AIH and showing signsof liver failure at diagnosis, immunosuppressive treatment led topermanent recovery of liver function. Liver transplantation could beavoided or delayed in most patients," the authors write.
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免疫抑制剂肝功能衰竭儿童受益
最后更新：2011年2月21日。

    自身免疫性肝炎的免疫抑制剂治疗的儿童最肝功能恢复


大多数儿童自身免疫性肝炎肝衰竭谁拥有免疫抑制治疗反应良好，并能延缓或避免肝脏移植手术，根据美国临床胃肠病学和肝病学杂志二月号发表的一项研究。

星期一，2月21日（大纪元新闻） - 大多数孩子自身免疫性肝炎（AIH）谁肝功能衰竭免疫抑制治疗反应良好，并能延缓或避免肝脏移植手术，根据美国临床胃肠病学和肝病学杂志二月号发表的一项研究。

仪属Cuarterolo医师，医院去Pediatría胡安体育Garrahan在布宜诺斯艾利斯，阿根廷，和同事分析了来自50个小儿AIH患者谁曾在1996年和2008年肝功能衰竭的数据。肝功能衰竭被定义为小于百分之五十凝血酶原时间。患者接受治疗2毫克/公斤，每天强的松的剂量高达每天60毫克或1毫克/公斤，每天多达40强的松每日加环孢素毫克。

研究者发现，这两个方法是同样有效。四十的儿童（百分之九十）五取得了24天，平均大于百分之五十凝血酶原时间。在这些患者中，两年，由于门脉高压并发症和三个必需的肝脏移植死于感染。五个无反应，三个接受器官移植，一个留在候补名单，以及一名来自中枢神经系统出血死亡。

“在与肝硬化继发于自身免疫性肝炎和肝功能衰竭的迹象，诊断，免疫治疗导致肝功能永久性恢复。肝脏移植的病人可以在大多数患者避免或延迟，”作者写道。

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