aspirin shown to prevent liver damage

keane

Aspirin shown to help prevent liver damage
27. January 2009 01:43

According to scientists at Yale University ordinary aspirin may help prevent liver damage in millions of people suffering from the side effects of common drugs, alcohol abuse and obesity-related liver disease.
The new study by researchers at Yale School of Medicine suggests that aspirin may help prevent and treat liver damage from a host of non-infectious causes.

Dr. Wajahat Mehal from the Digestive Diseases and Department of Immunobiology, says research with mice has shown that aspirin reduced the number of deaths caused by an overdose of acetaminophen, best known as paracetamol.

Dr. Mehal says many agents such as drugs and alcohol cause liver damage, and they found that aspirin blocks a central pathway responsible for such liver injury.

He says aspirin could be used on a daily basis to prevent liver injury and suggests that promising drugs which have failed clinical trials because of liver toxicity might be resurrected if combined with aspirin.

Dr. Mehal says the strategy offers the exciting possibility of reducing a lot of pain and suffering in patients with liver diseases, using a new and very practical approach.

Aspirin it seems counteracts new mechanisms of acetaminophen or paracetamol-induced liver damage - overdoses of acetaminophen account for most drug overdoses in most Western countries.

Such overdoses cause two waves of liver damage - the first wave of liver cell destruction is a result of the toxic nature of acetaminophen - the second wave is mediated by molecules of the immune system, which is activated in response to the initial acetaminophen-induced liver damage.

A daily aspirin is already recommended to prevent heart attacks in people at high risk of having one and recent research has shown that aspirin can help treat heart attacks - doses of between 75 milligrams and 325 milligrams help thin the blood; it has also been suggested women who take aspirin once a day may slightly reduce their risk of the most common type of breast cancer.

The study is published in the latest issue of the Journal of Clinical Investigation.

这篇文章的大意是说长期服用阿司匹林是有助于肝损害的预防对吗？ 你们觉得我们这些携带者是否可以服用啊

ybdn

没有用，文中说是用来对付非感染的肝病的，比如酒精引起的。

StephenW

回复 keane 的帖子

请非常小心!
过量的阿斯匹林可引起肝损害.
阿司匹林可导致内出血- 非常危险，如果你有肝硬化.

keane

hey， steve， 谢谢你的提醒，我没有肝硬化现在，你觉得 我如果每天一个阿司匹林，对肝脏有影响吗？身边有些鬼同事在吃，他们说吃了对身体很好，可以预防癌症，心脏病等等。

StephenW

回复 keane 的帖子

请向你的医生.提到对肝脏的影响.据医生，使用推荐剂量阿司匹林是安全的，即使B型肝炎病人。但请注意:许多其他药物，如感冒药，止痛药，可能包括阿司匹林。如果加在一起，可以超过建议的每日剂量.

bigben446

keane 发表于 2011-2-6 09:07
Aspirin shown to help prevent liver damage
27. January 2009 01:43

暂且不论他的实质内容是什么，他说的是“a host of non-infectious causes”，是对于非感染性的肝损害（文章作者明确排除了乙肝、丙肝等感染性肝损害），研究报告千奇八怪，某种意义上也是科研创新的体现，姑且不论这篇报告的内容、细节，但是凭这样一个报告自我决定吃药与否，风险太大了。