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任何吃进去的东西都要通过肝脏，一般剂量和正常使用不会。而且Viagra是选择性阻碍某个部位的血液，对肝脏，脾脏血流没有影响。和其他任何药物一样，新药开始后需要定期检查肝脏指数。
这个文献是关于选择性阻碍血流，不影响肝硬化患者脾，肝系统血流的：
Viagra has no effect on patients with chronic end-stage liver disease
Wed Nov 12 2008 03:50:00 GMT-0800 (Pacific Standard Time) by ANI ( Leave a comment )
Washington, Nov 12 (ANI): In a new study, scientists have established that sildenafil, a drug also sold as Viagra and known for treating erectile dysfunction (male impotence) and pulmonary arterial hypertension (PAH), does not influence blood flow in patients with cirrhosis.
Erectile dysfunction is a common problem affecting about half of all patients with end-stage liver disease.
The scientists found that sildenafil had no effect on the hepatic venous pressure gradient (HVPG).
In the study, the scientists aimed at finding if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient (HVPG) in patients with cirrhosis.
The study was conducted on ten patients with biopsy proven cirrhosis and an HVPG above 12 mmHg.
The scientists then measured the splanchnic blood flow and the HVPG during liver vein catheterization before and 80 min after oral administration of 50 mg sildenafil.
Blood flow was estimated by use of indocyanine green clearance technique and Fick’’s principle, with correction for non-steady state.
Though the scientists saw a decrease in arterial blood pressure80 min after administration of the phosphodiesterase type-5 inhibitor sildenafil, they were unable to demonstrate any clinical relevant influence on splanichnic blood flow, oxygen consumption or the HVPG.
It was known that selective phosphodiesterase type-5 inhibitors, such as sildenafil, represent an important advance in management of erectile dysfunction.
Scientists measured the HVPG and the estimation of splanchnic blood flow of the participants before and 80 min after oral administration of 50 mg of sildenafil.
This study reports the effects of sildenafil on the splanchnic hemodynamics in patients with biopsy proven cirrhosis and manifest portal hypertension.
Despite a small decrease in mean arterial pressure, the main finding in this study was that the splanchnic blood flow, oxygen consumption and the mean HVPG did not change 80 min after administration of sildenafil, i.e. at a time-point when a therapeutic plasma concentration of sildenafil could be documented.
The study shows that sildenafil does not induce any profound clinically relevant changes in splanchnic blood flow, oxygen consumption and HVPG.
The authors concluded that phosphodiesterase type-5 inhibition is of no use as a therapeutic agent for alleviating portal hypertension in patients with chronic end-stage liver disease. (ANI) |
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发表于 2011-1-30 19:08
