《探索》杂志评出2006年12项重大生物学发现 2006年12月21日 http://tech.sina.com.cn/d/2006-12-21/07201298895.shtml 2.老鼠身上发现新器官 老鼠是最为常见的实验动物,经常被开肠破肚,但生物学家从未想到会在几乎每天都要接触的老鼠身上发现新器官。2006年4月,德国乌尔姆大学免疫学家汉斯-雷默·罗德瓦尔德(Hans-Reimer Rodewald)宣布,他在解剖胸部胸腺存在疾患的实验鼠时,发现了另一处胸腺——颈部胸腺。两个胸腺器官都要产生成称为T淋巴球的免疫细胞。新发现的器官位于颈部,只是老鼠胸部胸腺大小的几分之一。 罗德瓦尔德说:“当我们第一次见到它时,我简直难以置信。”为了查看它是否真正发挥功能的器官,罗德瓦尔德的研究小组将正常老鼠身上的小胸腺移植到没有胸腺、发生过变异的动物身上。当他们向这些动物注射了一种来自B型肝炎疫苗的蛋白质时,它们就会产生免疫反应。生物学家目前正在展开大规模排查,试图发现第二种也许同样被忽视的人类器官。 http://www.discover.com/issues/jan-07/features/biology/ New Mouse Organ Found Mice are the most common lab animal, dissected so frequently that no biologist expects to stumble upon a new organ. But in April 2006, Hans-Reimer Rodewald, an immunologist at the University of Ulm in Germany, reported that mice have two thymus organs—one of them somehow undiscovered—and that both can produce immune cells called T lymphocytes. Located in the neck, the newfound organ is a fraction of the size of the long-familiar thymus found in the mouse's chest. "When we first saw this, I didn't believe it," says Rodewald. To see whether it was a true functional organ, his team transplanted the small thymus from normal mice into mutant, thymus-free animals. When they injected these animals with a protein from the hepatitis B vaccine, the animals produced an immune response. Biologists are checking to see if they have overlooked a second human organ too. 德国乌尔姆大学免疫学 http://www.uni-ulm.de/klinik/immunologie/general.htm 胸腺类制剂 http://www.hbvhbv.com/forum/viewthread.php?tid=619030 |