用于DNA疫苗设计的基于生物聚合物的载体

StephenW

Biopolymer-based Carriers for DNA Vaccine Design
Ljiljana Fruk  1 , Christoph O Franck  2 , Luise Fanslau  2 , Andrea Bistrovic Popov  2 , Puneet Tyagi  3
Affiliations

    PMID: 32893932 DOI: 10.1002/anie.202010282

Abstract

Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites and cancers. However, the clinical breakthrough of the technique is confined by the low transfection efficacy and immunogenicity of the employed vaccines. Therefore, carrier materials were designed to prevent the rapid degradation and systemic clearance of DNA in the body. In this context, biopolymers are a particularly promising DNA vaccine carrier platform, due to their beneficial biochemical and physical characteristics, including biocompatibility, stability and low toxicity. This article reviews the applications, fabrication and modification of biopolymers as carrier medium for genetic vaccines.

Keywords: DNA vaccines; biopolymers; gene delivery; immunotherapy; nanostructures.

© 2020 Wiley-VCH GmbH.

StephenW

用于DNA疫苗设计的基于生物聚合物的载体
Ljiljana Fruk 1，Christoph O Franck 2，Luise Fanslau 2，Andrea Bistrovic Popov 2，Puneet Tyagi 3
隶属关系

    PMID：32893932 DOI：10.1002 / anie.202010282

抽象

在过去的30年中，基因工程DNA已作为针对多种疾病的新型疫苗接种策略进行了测试，其中包括人类免疫缺陷病毒（HIV），乙型肝炎，多种寄生虫和癌症。但是，该技术的临床突破仅限于所用疫苗的低转染效力和免疫原性。因此，设计载体材料以防止体内DNA的快速降解和全身清除。在这种情况下，生物聚合物由于其有益的生化和物理特性（包括生物相容性，稳定性和低毒性）而成为特别有前途的DNA疫苗载体平台。本文综述了生物聚合物作为遗传疫苗载体的应用，制备和修饰。

关键词：DNA疫苗；生物聚合物基因传递；免疫疗法纳米结构。

©2020 Wiley-VCH GmbH。