乙肝病毒复制的生物标志物概述和对未来的展望

StephenW

Biomarkers for hepatitis B virus replication an overview and a look to the future
Feng-Cai Li  1 , Yue-Kai Li  2 , Yu-Chen Fan  1   3
Affiliations

    PMID: 32887529 DOI: 10.1080/17474124.2020.1815530

Abstract

Introduction: Hepatitis B virus(HBV) infection is a major public health issue but there are no powerful drugs to eradicate the virus. HBV markers including HBsAg, HBcrAg, HBV RNA, HBcAb and HBV DNA are becoming promising biomarkers to reflect the natural phases of chronic HBV infection and predict the outcome of anti-HBV treatment.

Areas covered: The authors summarized the biomarkers of HBV replication and presented the current advances of these biomarkers on predicting the outcome of anti-HBV treatment and identifying the progression of chronic HBV infection.

Expert opinion: HBsAg, HBcrAg, HBV RNA, HBcAb and HBV DNA are noninvasive and feasible biomarkers for monitoring the process of anti-HBV therapy and predicting the progress of HBV infection. However, there are still no strong biomarkers with high sensitivity and specificity for clinical application. Combination of two or more HBV biomarkers, new technique for measuring HBV cccDNA, and searching novel HBV biomarkers are essential for anti-HBV treatment in the future.

Keywords: Biomarker; Covalently closed circular DNA; HBV DNA; HBV RNA; HBcAb; HBcrAg; HBsAg; Hepatitis B Virus; Immune stages.

StephenW

乙肝病毒复制的生物标志物概述和对未来的展望
李凤才1，李月凯2，范玉晨1 3
隶属关系

    PMID：32887529 DOI：10.1080 / 17474124.2020.1815530

抽象

简介：乙型肝炎病毒（HBV）感染是主要的公共卫生问题，但目前尚无能根除该病毒的有效药物。包括HBsAg，HBcrAg，HBV RNA，HBcAb和HBV DNA在内的HBV标记正成为有前途的生物标记，以反映慢性HBV感染的自然阶段并预测抗HBV治疗的结果。

涵盖的领域：作者总结了HBV复制的生物标志物，并介绍了这些生物标志物在预测抗HBV治疗结果和确定慢性HBV感染进展方面的最新进展。

专家意见：HBsAg，HBcrAg，HBV RNA，HBcAb和HBV DNA是用于监测抗HBV治疗过程和预测HBV感染进展的非侵入性可行生物标记。然而，仍然没有针对临床应用具有高灵敏度和特异性的强生物标志物。两种或多种HBV生物标志物的组合，用于测量HBV cccDNA的新技术以及寻找新的HBV生物标志物对于将来的抗HBV治疗至关重要。

关键词：生物标志物；共价封闭的环状DNA； HBV DNA； HBV RNA； HBcAb； HBcrAg;乙肝表面抗原乙型肝炎病毒;免疫阶段。