细胞因子预测接受聚乙二醇干扰素α-2a治疗的慢性乙型肝炎

StephenW

Cytokines Predict Virological Response in Chronic Hepatitis B Patients Receiving Peginterferon alfa-2a Therapy
Wen-Kang Fu  1 , Jie Cao  1 , Ning-Ning Mi  1 , Chong-Fei Huang  1 , Long Gao  1 , Jin-Duo Zhang  2 , Ping Yue  2 , Bing Bai  2 , Yan-Yan Lin  2 , Wen-Bo Meng  1
Affiliations
Affiliations

    1
    The First Clinical Medical School, Lanzhou University, Lanzhou 730000, Gansu Province, China.
    2
    Special Minimally Invasive Surgery Department, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.

    PMID: 32548156 PMCID: PMC7281045 DOI: 10.12998/wjcc.v8.i11.2255

Abstract

Background: Chronic hepatitis B virus infection remains a major global public health problem. Peginterferon-alpha-2a (PEG-IFN) has direct antiviral and immunoregulatory effects, and it has become one of the first choice drugs for the treatment of chronic hepatitis B (CHB). Cytokines play an important role in immunity, and they directly inhibit viral replication and indirectly determine the predominant pattern of the host immune response.

Aim: To determine the correlation between cytokine/chemokine expression levels and response to PEG-IFN treatment in patients with CHB.

Methods: Forty-six kinds of cytokines were analyzed before PEG-IFN therapy and at 24 wk during therapy in 26 CHB patients.

Results: The monokine induced by INF-γ (CXCL9) and serum interferon-inducible protein 10 ( IP-10) levels at baseline were higher in virological responders than in non-virological responders (NRs) and decreased during treatment, whereas the NRs did not exhibit significant changes. The macrophage inflammatory protein 1d (MIP-1d) levels at baseline and during treatment were significantly higher in the virological responders than in the NRs, while thymus and activation-regulated chemokine (TARC) levels at baseline and during treatment were significantly lower in the virological responders than in the NRs. The CXCL9, IP-10, MIP-1d, and TARC baseline levels exhibited the expected effects for interferon treatment. The area under the receiver operating characteristic curve values of CXCL9, IP-10, MIP-1d, and TARC for predicting virological responses were 0.787, 0.799, 0.787, and 0.77 (P = 0.01, 0.013, 0.01, and 0.021), respectively.

Conclusion: We found that cytokine levels before and during treatment may represent potential biomarkers to select CHB patients who can respond to PEG-IFN. Therefore, cytokines can be used as an indicator of antiviral drug selection before CHB treatment.

Keywords: CXCL9; Chronic hepatitis B; Cytokine/chemokine; Interferon-inducible protein 10; Peginterferon-alpha-2a; Thymus and activation-regulated chemokine.

©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

StephenW

细胞因子预测接受聚乙二醇干扰素α-2a治疗的慢性乙型肝炎患者的病毒学应答。
傅文康1，曹杰1，米宁宁1，黄崇飞1，龙高1，张金铎2，平Jin 2，白冰2，林艳艳2，孟文博1个
隶属关系
隶属关系

    1个
    兰州大学第一临床医学院，甘肃兰州730000
    2
    兰州大学第一医院特殊微创外科，甘肃兰州730000

    PMID：32548156 PMCID：PMC7281045 DOI：10.12998 / wjcc.v8.i11.2255

抽象

背景：慢性乙型肝炎病毒感染仍然是全球主要的公共卫生问题。聚乙二醇干扰素-α-2a（PEG-IFN）具有直接的抗病毒和免疫调节作用，已成为治疗慢性乙型肝炎（CHB）的首选药物之一。细胞因子在免疫中起重要作用，它们直接抑制病毒复制并间接确定宿主免疫反应的主要模式。

目的：确定CHB患者细胞因子/趋化因子表达水平与对PEG-IFN治疗的反应之间的相关性。

方法：对26例CHB患者进行PEG-IFN治疗前和治疗期间24周共分析了46种细胞因子。

结果：基线时，由INF-γ（CXCL9）诱导的单因子和血清干扰素诱导蛋白10（IP-10）水平在病毒应答者中高于非病毒应答者（NRs），并在治疗期间降低，而NRs确实没有明显的变化。在病毒学应答者中，基线和治疗期间巨噬细胞炎症蛋白1d（MIP-1d）水平明显高于NRs，而在基线和治疗期间，胸腺和活化调节趋化因子（TARC）水平在病毒学应答者中显着降低响应者比NRs中的要多。 CXCL9，IP-10，MIP-1d和TARC基线水平表现出预期的干扰素治疗效果。 CXCL9，IP-10，MIP-1d和TARC的接收器工作特征曲线值下用于预测病毒应答的面积分别为0.787、0.799、0.787和0.77（P = 0.01、0.013、0.01和0.021）。

结论：我们发现治疗前和治疗过程中的细胞因子水平可能代表了选择对PEG-IFN有反应的CHB患者的潜在生物标志物。因此，在CHB治疗之前，可以将细胞因子用作抗病毒药物选择的指标。

关键字：CXCL9;慢性乙型肝炎；细胞因子/趋化因子；干扰素诱导蛋白10;聚乙二醇干扰素-α-2a;胸腺和激活调节趋化因子。

©作者2020。由百世登出版集团有限公司出版。保留所有权利。

StephenW

https://doi.org/10.12998/wjcc.v8.i11.2255