正大天晴启动ETV+TLR7+PD-L1联合用药二期临床试验

sir

1、Combination of ETV, TQ-A3334 and TQ-B2450 for CHB (Neptune Study) (Neptune)，2期，24周

2、A Study of TQ-A3334 Combined With Entecavir in the Treatment of Chronic Hepatitis B，2期，24周

Active Comparator: Naive:ETVEntecavir 0.5 mg po daily for 24 weeks in naive patients	Drug: ETVentecavir 0.5 mg qd
Experimental: Naive:ETV+TQ-A3334Entecavir 0.5 mg po daily plus TQ-A3334 for 24 weeks in naive patients	Drug: ETVentecavir 0.5 mg qd Drug: TQ-A3334TQ-A3334 po qw
Experimental: Naive:ETV+TQ-A3334+TQ-B2450Entecavir 0.5 mg po daily plus TQ-A3334 plus inhibitor of TQ-B2450 for 24 weeks in naive patients	Drug: ETVentecavir 0.5 mg qd Drug: TQ-A3334TQ-A3334 po qw Drug: TQ-B2450TQ-B2450 q3w iv
Active Comparator: Experienced:ETVEntecavir 0.5 mg po daily for 24 weeks in treatment experienced patients	Drug: ETVentecavir 0.5 mg qd
Experimental: Experienced:ETV+TQ-A3334Entecavir 0.5 mg po daily plus TQ-A3334 for 24 weeks in treatment experienced patients	Drug: ETVentecavir 0.5 mg qd Drug: TQ-A3334TQ-A3334 po qw
Experimental: Experienced:ETV+TQ-A3334+TQ-B2450Entecavir 0.5 mg po daily plus TQ-A3334 plus TQ-B2450 for 24 weeks in treatment experienced patients	Drug: ETVentecavir 0.5 mg qd Drug: TQ-A3334TQ-A3334 po qw Drug: TQ-B2450TQ-B2450 q3w iv

Outcome Measures

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Primary Outcome Measures
:

• Change from baseline in HBsAg quantification at week 24 [ Time Frame: week 24 ]HBsAg quantification are measured
  

Secondary Outcome Measures
:

• HBsAg loss rates at week 24 [ Time Frame: week 24 ]HBsAg loss rates are measured
• HBsAg seroconversion rates at week 24 [ Time Frame: week 24 ]HBsAg seroconversion rates are measured
• HBeAg loss rates at week 24 [ Time Frame: week 24 ]HBeAg loss rates are measured
• HBeAg seroconversion rates at week 24 [ Time Frame: week 24 ]HBeAg seroconversion rates are measured
• HBV DNA<20IU/mL rates at week 24 [ Time Frame: week 24 ]HBV DNA<20IU/mL rates are measured
  

                                                                                                                                                                                                
                                       
                                
                        
               

newchinabok

sir 发表于 2020-1-5 00:14
1、Combination of ETV, TQ-A3334 and TQ-B2450 for CHB (Neptune Study) (Neptune)，2期，24周

2、A Stud ...

感谢分享，可惜看不懂。我只懂河南话，有没河南话版本的，哈哈。

newchinabok

俺说的双免疫，中

灵魂不屈

感谢分享，期待能有好消息。

齐欢畅

windu

中！！！

乙肝人1949

现在可以利用小刀步枪有限组合，试图试一试，阔以

newchinabok

乙肝人1949 发表于 2020-1-5 20:26
现在可以利用小刀步枪有限组合，试图试一试，阔以

目前组合不成功，所以思考双免疫，会有更多组合出现

乙肝人1949

目前医生可以用于治疗的手段太少了，核苷和干扰素，出现免疫药还未过三期，不过太难为医生了，想想，医生象厨师，就那么点土豆，黄瓜，还要做出满汉全席的效果，医生好难哦

左罗

既然是在中国的企业，可否使用中文阐述介绍，岂不更方便、更好懂、更有利于大家参与讨论吗？