Immune‐Tolerant CHB 免疫耐受期 |
1. HBsAg present for ≥6 months HBsAg阳性超过6个月 |
2. HBeAg positive HBeAg 阳性 |
3. HBV‐DNA levels are very high (typically >1 million IU/mL). 高HABV-DNA(典型为大于1,000,000IU/ML) |
4. Normal or minimally elevated ALT and/or AST ALT和/或AST 正常或轻度升高 |
4. Liver biopsy or noninvasive test results showing no fibrosis and minimal inflammation 无纤维化和非常轻微炎症 |
Immune‐Active CHB 免疫活动期(清除期) |
1. HBsAg present for ≥6 months HBsAg阳性超过6个月 |
2. Serum HBV DNA >20,000 IU/mL in HBeAg‐positive CHB and >2,000 IU/mL in HBeAg‐negative CHB
HBeAg阳性的慢性乙肝患者DNA 大于20,000 IU/mL; HBeAg阴性的慢性乙肝病人DNA大于2000IU/ml |
3. Intermittently or persistently elevated ALT and/or AST levels ALT和/或AST 间歇性的或者持久的升高。 |
4. Liver biopsy or noninvasive test results show chronic hepatitis with moderate or severe necroinflammation and with or without fibrosis 肝活检或无创检查结果有中度或严重的炎症坏死,伴有或不伴有肝纤维化。 |