日本乙型肝炎病毒感染者的肝细胞癌发病率在长期基因型B和C

StephenW

J Viral Hepat. 2019 Mar 28. doi: 10.1111/jvh.13099. [Epub ahead of print]
Incidence of development of hepatocellular carcinoma in Japanese patients infected with hepatitis B virus are equivalent between genotype B and C in long term.
Haga H1, Saito T1,2, Okumoto K1, Tomita K1, Katsumi T1, Mizuno K1, Nishina T1, Watanabe H1, Ueno Y1.
Author information

1
    Department of Gastroenterology, Yamagata University, Faculty of Medicine, Yamagata, Yamagata, 990-9585, Japan.
2
    School of Nursing, Yamagata University, Faculty of Medicine, Yamagata, Yamagata, 990-9585, Japan.

Abstract

Hepatitis B virus (HBV) genotypes B (HBV/B) and C (HBV/C) are the most prevalent genotypes among Japanese patients with hepatitis. Reportedly, HBV/C infection has been associated with more severe disease progression, manifesting as developing cirrhosis and hepatocellular carcinoma (HCC), than HBV/B infection. However, no long-term studies have examined the development of HCC in HBV/B-infected patients in Japan. The aims of our study were to compare the incidence of HCC in HBV/B or HBV/C-infected patients. A total of 241 patients were followed up among 295 hepatitis B surface antigen (HBsAg)-positive carriers. Genotypes of HBV were A in 1% (4/295), B in 61% (179/295), C in 37% (110/295), and D in 1% (2/295) patients, and 96% of HBV/B were infected with subgenotype Bj. The mean age at HCC diagnosis was significantly higher in HBV/B than in HBV/C (67.0 ± 10.0 vs. 57.7 ± 8.0 years, p < 0.001). The value of FIB-4 index index was significantly higher in HBV/B than in HBV/C (p < 0.01). The rate of HCC was higher in HBV/C than in HBV/B, and a significant difference was observed until the 20-year observation period (p = 0.048). However, thereafter, HCC associated with HBV/B increased, and no significant difference was observed between HBV/B and HBV/C. HCC development was consistently observed even in HBV/B infection, especially among elderly patients with advanced fibrosis compared with HBV/C. HBV/B-infected patients developed HCC later in life, and in the long term, we found no differences in incidence of HCC development rates between these two genotypes. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

StephenW

J病毒肝病。 2019年3月28日doi：10.1111 / jvh.13099。 [印刷前的电子版]
日本乙型肝炎病毒感染者的肝细胞癌发病率在长期基因型B和C之间是相同的。
Haga H1，Saito T1,2，Okumoto K1，Tomita K1，Katsumi T1，Mizuno K1，Nishina T1，Watanabe H1，Ueno Y1。
作者信息

1
山形大学消化科，日本山形县山形医学部，990-9585。
2
山形大学医学部护理学院山形县山形县，990-9585，日本。

抽象

乙型肝炎病毒（HBV）基因型B（HBV / B）和C（HBV / C）是日本肝炎患者中最常见的基因型。据报道，HBV / C感染与更严重的疾病进展有关，表现为发展为肝硬化和肝细胞癌（HCC），而不是HBV / B感染。然而，没有长期研究检查日本HBV / B感染患者的HCC发展。我们的研究目的是比较HBV / B或HBV / C感染患者的HCC发病率。共有241名患者接受了295例乙型肝炎表面抗原（HBsAg）阳性携带者的随访。 HBV的基因型为A 1％（4/295），B为61％（179/295），C为37％（110/295），D为1％（2/295）患者，96％ HBV / B感染亚基因型Bj。 HBV / B的HCC诊断平均年龄显着高于HBV / C（67.0±10.0 vs. 57.7±8.0岁，p <0.001）。 HBV / B中FIB-4指数指数显着高于HBV / C（p <0.01）。 HBV / C中HCC的发生率高于HBV / B，并且在20年观察期之前观察到显着差异（p = 0.048）。然而，此后，与HBV / B相关的HCC增加，并且在HBV / B和HBV / C之间未观察到显着差异。即使在HBV / B感染中也一直观察到HCC发展，尤其是与HBV / C相比晚期纤维化的老年患者。 HBV / B感染的患者晚年发生HCC，从长远来看，我们发现这两种基因型之间HCC发病率的发生率没有差异。本文受版权保护。

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